巴西亚马逊地区人群对间日疟原虫达菲结合蛋白（DBP）天然抗体的检测
Naturally acquired antibodies to Plasmodium vivax Duffy binding protein (DBP) in Brazilian Amazon.
机构信息
Centro de Pesquisas René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Minas Gerais, Brazil.
出版信息
Am J Trop Med Hyg. 2010 Feb;82(2):185-93. doi: 10.4269/ajtmh.2010.08-0580.
Abstract
Duffy binding protein (DBP), a leading malaria vaccine candidate, plays a critical role in Plasmodium vivax erythrocyte invasion. Sixty-eight of 366 (18.6%) subjects had IgG anti-DBP antibodies by enzyme-linked immunosorbent assay (ELISA) in a community-based cross-sectional survey in the Brazilian Amazon Basin. Despite continuous exposure to low-level malaria transmission, the overall seroprevalence decreased to 9.0% when the population was reexamined 12 months later. Antibodies from 16 of 50 (36.0%) subjects who were ELISA-positive at the baseline were able to inhibit erythrocyte binding to at least one of two DBP variants tested. Most (13 of 16) of these subjects still had inhibitory antibodies when reevaluated 12 months later. Cumulative exposure to malaria was the strongest predictor of DBP seropositivity identified by multiple logistic regression models in this population. The poor antibody recognition of DBP elicited by natural exposure to P. vivax in Amazonian populations represents a challenge to be addressed by vaccine development strategies.
摘要
达菲结合蛋白（DBP）是一种主要的疟疾候选疫苗，在间日疟原虫红细胞入侵中发挥关键作用。在巴西亚马逊流域的一项基于社区的横断面调查中，通过酶联免疫吸附试验（ELISA），366 名受试者中有 68 名（18.6%）具有 IgG 抗 DBP 抗体。尽管持续接触低水平的疟疾传播，但当人群在 12 个月后再次检查时，总体血清阳性率下降到 9.0%。在基线时 ELISA 阳性的 50 名受试者中有 16 名（36.0%）的抗体能够抑制红细胞与至少两种 DBP 变体中的一种结合。在 12 个月后再次评估时，这些受试者中的大多数（13 名中的 13 名）仍具有抑制性抗体。在该人群中，多元逻辑回归模型确定，疟疾的累积暴露是 DBP 血清阳性的最强预测因素。在亚马逊人群中，自然感染间日疟原虫引起的 DBP 抗体识别不良，这是疫苗开发策略需要解决的挑战。
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