离子型谷氨酸受体辅助亚基的调节作用。
Regulation of ionotropic glutamate receptors by their auxiliary subunits.
机构信息
Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
Physiology (Bethesda). 2010 Feb;25(1):41-9. doi: 10.1152/physiol.00033.2009.
Abstract
Glutamate receptors are major excitatory receptors in the brain. Recent findings have established auxiliary subunits of glutamate receptors as critical modulators of synaptic transmission, synaptic plasticity, and neurological disorder. The elucidation of the molecular rules governing glutamate receptors and subunits will improve our understanding of synapses and of neural-circuit regulation in the brain.
摘要
谷氨酸受体是大脑中的主要兴奋性受体。最近的研究发现，谷氨酸受体的辅助亚基是突触传递、突触可塑性和神经紊乱的关键调节因子。阐明调节谷氨酸受体和亚基的分子规则将有助于我们理解突触以及大脑中神经回路的调节。
相似文献
1
Regulation of ionotropic glutamate receptors by their auxiliary subunits.离子型谷氨酸受体辅助亚基的调节作用。
Physiology (Bethesda). 2010 Feb;25(1):41-9. doi: 10.1152/physiol.00033.2009.
2
Auxiliary subunits assist AMPA-type glutamate receptors.辅助亚基协助AMPA型谷氨酸受体。
Science. 2006 Mar 3;311(5765):1253-6. doi: 10.1126/science.1123339.
3
AMPA receptor structure and auxiliary subunits.AMPA 受体结构与辅助亚基。
J Physiol. 2021 Jan;599(2):453-469. doi: 10.1113/JP278701. Epub 2020 Feb 18.
4
The regulation of glutamate receptor trafficking and function by TARPs and other transmembrane auxiliary subunits.TARPs 和其他跨膜辅助亚基对谷氨酸受体转运和功能的调节。
Curr Opin Neurobiol. 2012 Jun;22(3):488-95. doi: 10.1016/j.conb.2011.09.005. Epub 2011 Oct 10.
5
Structure and function of glutamate receptors.谷氨酸受体的结构与功能。
Ann N Y Acad Sci. 2004 Dec;1038:125-30. doi: 10.1196/annals.1315.020.
6
Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins.AMPA 型谷氨酸受体及其辅助蛋白的结构和功能架构。
Neuron. 2017 May 17;94(4):713-730. doi: 10.1016/j.neuron.2017.04.009.
7
Modulation of information processing by AMPA receptor auxiliary subunits.AMPA 受体辅助亚基对信息处理的调制。
J Physiol. 2021 Jan;599(2):471-483. doi: 10.1113/JP276698. Epub 2020 Jul 24.
8
Genomic control of receptor function.受体功能的基因组控制。
Cell Mol Life Sci. 2000 Oct;57(11):1499-507. doi: 10.1007/pl00000634.
9
Exploring the role of AMPA receptor auxiliary proteins in synaptic functions and diseases.探索AMPA受体辅助蛋白在突触功能和疾病中的作用。
FEBS J. 2025 May;292(10):2433-2478. doi: 10.1111/febs.17287. Epub 2024 Oct 11.
10
Auxiliary subunits keep AMPA receptors compact during activation and desensitization.辅助亚基在 AMPA 受体的激活和脱敏过程中保持其结构紧凑。
Elife. 2018 Dec 6;7:e40548. doi: 10.7554/eLife.40548.
引用本文的文献
1
AMPA Receptor Modulation in the Treatment of High-Grade Glioma: Translating Good Science into Better Outcomes.AMPA受体调节在高级别胶质瘤治疗中的应用：将优秀科学转化为更好的治疗结果
Pharmaceuticals (Basel). 2025 Mar 8;18(3):384. doi: 10.3390/ph18030384.
2
Local BMP signaling: A sensor for synaptic activity that balances synapse growth and function.局部 BMP 信号：一种用于平衡突触生长和功能的突触活动传感器。
Curr Top Dev Biol. 2022;150:211-254. doi: 10.1016/bs.ctdb.2022.04.001. Epub 2022 May 18.
3
Imaging of Transmembrane AMPA Receptor Regulatory Proteins by Positron Emission Tomography.正电子发射断层扫描技术对跨膜 AMPA 受体调节蛋白的成像。
J Med Chem. 2022 Jul 14;65(13):9144-9158. doi: 10.1021/acs.jmedchem.2c00377. Epub 2022 Jun 28.
4
Neurodevelopmental Disorders Associated with PSD-95 and Its Interaction Partners.与 PSD-95 及其相互作用伙伴相关的神经发育障碍。
Int J Mol Sci. 2022 Apr 15;23(8):4390. doi: 10.3390/ijms23084390.
5
The Calcium Channel Subunit Gamma-4 as a Novel Regulator of MafA in Pancreatic Beta-Cell Controls Glucose Homeostasis.钙通道亚基γ-4作为胰腺β细胞中MafA的新型调节因子控制葡萄糖稳态。
Biomedicines. 2022 Mar 25;10(4):770. doi: 10.3390/biomedicines10040770.
6
Tetraspanins as Potential Modulators of Glutamatergic Synaptic Function.四跨膜蛋白作为谷氨酸能突触功能的潜在调节因子。
Front Mol Neurosci. 2022 Jan 3;14:801882. doi: 10.3389/fnmol.2021.801882. eCollection 2021.
7
Torpor enhances synaptic strength and restores memory performance in a mouse model of Alzheimer's disease.昏睡可增强阿尔茨海默病小鼠模型的突触强度并恢复记忆表现。
Sci Rep. 2021 Jul 29;11(1):15486. doi: 10.1038/s41598-021-94992-x.
8
Regulation of GABARs by Transmembrane Accessory Proteins.跨膜辅助蛋白对 GABARs 的调节。
Trends Neurosci. 2021 Feb;44(2):152-165. doi: 10.1016/j.tins.2020.10.011. Epub 2020 Nov 21.
9
AMPA receptor auxiliary subunits emerged during early vertebrate evolution by neo/subfunctionalization of unrelated proteins.AMPA 受体辅助亚基通过无关蛋白的新/功能化在早期脊椎动物进化中出现。
Open Biol. 2020 Oct;10(10):200234. doi: 10.1098/rsob.200234. Epub 2020 Oct 28.
10
The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation.辅助谷氨酸受体亚基 dSol-1 促进突触前神经递质释放和同型突触增强。
Proc Natl Acad Sci U S A. 2020 Oct 13;117(41):25830-25839. doi: 10.1073/pnas.1915464117. Epub 2020 Sep 24.
本文引用的文献
1
TARP modulation of synaptic AMPA receptor trafficking and gating depends on multiple intracellular domains.TARP对突触AMPA受体转运和门控的调节取决于多个细胞内结构域。
Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11348-51. doi: 10.1073/pnas.0905570106. Epub 2009 Jun 22.
2
Roles of stargazin and phosphorylation in the control of AMPA receptor subcellular distribution.stargazin和磷酸化在AMPA受体亚细胞分布调控中的作用。
Nat Neurosci. 2009 Jul;12(7):888-96. doi: 10.1038/nn.2340. Epub 2009 Jun 21.
3
The stoichiometry of AMPA receptors and TARPs varies by neuronal cell type.AMPA受体与跨膜 AMPA 受体调节蛋白（TARPs）的化学计量因神经元细胞类型而异。
Neuron. 2009 Jun 11;62(5):633-40. doi: 10.1016/j.neuron.2009.05.016.
4
Functional proteomics identify cornichon proteins as auxiliary subunits of AMPA receptors.功能蛋白质组学鉴定出柯尼希氏蛋白为AMPA受体的辅助亚基。
Science. 2009 Mar 6;323(5919):1313-9. doi: 10.1126/science.1167852.
5
Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning.Neto1是一种新型的CUB结构域NMDA受体相互作用蛋白，是突触可塑性和学习所必需的。
PLoS Biol. 2009 Feb 24;7(2):e41. doi: 10.1371/journal.pbio.1000041.
6
Selective regulation of long-form calcium-permeable AMPA receptors by an atypical TARP, gamma-5.一种非典型跨膜 AMPA 受体调节蛋白γ-5 对长型钙通透性 AMPA 受体的选择性调控
Nat Neurosci. 2009 Mar;12(3):277-85. doi: 10.1038/nn.2266. Epub 2009 Feb 22.
7
A transmembrane accessory subunit that modulates kainate-type glutamate receptors.一种调节红藻氨酸型谷氨酸受体的跨膜辅助亚基。
Neuron. 2009 Feb 12;61(3):385-96. doi: 10.1016/j.neuron.2008.12.014.
8
Autoinactivation of neuronal AMPA receptors via glutamate-regulated TARP interaction.通过谷氨酸调节的TARP相互作用实现神经元AMPA受体的自动失活。
Neuron. 2009 Jan 15;61(1):101-12. doi: 10.1016/j.neuron.2008.11.009.
9
Loss of inhibitory neuron AMPA receptors contributes to ataxia and epilepsy in stargazer mice.抑制性神经元AMPA受体的丧失导致了stargazer小鼠的共济失调和癫痫。
J Neurosci. 2008 Oct 15;28(42):10599-603. doi: 10.1523/JNEUROSCI.2732-08.2008.
10
Evolutionary conserved role for TARPs in the gating of glutamate receptors and tuning of synaptic function.TARPs在谷氨酸受体门控和突触功能调节中具有进化保守作用。
Neuron. 2008 Sep 25;59(6):997-1008. doi: 10.1016/j.neuron.2008.07.023.
Zotero 插件