Department of Pediatrics, Comenius University in Bratislava, Jessenius School of Medicine, Martin, Slovakia.
J Physiol Pharmacol. 2009 Nov;60 Suppl 5:61-5.
Cough is a major symptom in some children with asthma, but the relationship between cough and the severity of asthma is defined insufficiently. As cough represents common problem of pediatrics, several objective methods for its assessment were developed. Cough reflex sensitivity (CRS) test with capsaicin is one of the most important tools for studying cough. In the present study, we aimed to study the CRS in various phenotypes of childhood asthma. We found that, in general, CRS was increased in asthmatic children compared with controls. The most evident increase of CRS was observed during acute asthma exacerbation, in children suffering from asthma with concomitant allergic rhinitis, and in atopic asthmatics. Interestingly, we noted a significant decline in lung function after capsaicin CRS. Various laboratory and clinical characteristics of asthmatic children influence cough sensitivity to a different extent. Cough reflex sensitivity measurement can add valuable information beside the commonly used spirometric and inflammometric methods in the management of asthmatic children.
咳嗽是一些哮喘儿童的主要症状，但咳嗽与哮喘严重程度之间的关系定义不充分。由于咳嗽是儿科常见的问题，因此已经开发了几种用于评估咳嗽的客观方法。辣椒素诱导的咳嗽反射敏感性（CRS）测试是研究咳嗽的最重要工具之一。在本研究中，我们旨在研究儿童哮喘的各种表型中的 CRS。我们发现，与对照组相比，哮喘儿童的 CRS 通常增加。在哮喘急性加重期间、患有伴有过敏性鼻炎的哮喘儿童以及特应性哮喘儿童中，CRS 的增加最为明显。有趣的是，我们注意到 CRS 后肺功能显著下降。哮喘儿童的各种实验室和临床特征对咳嗽敏感性的影响程度不同。除了常用的肺活量和炎症计量方法外，CRS 测量可在哮喘儿童的管理中提供有价值的信息。
