Department of General Surgery, Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, China.
Int J Gynecol Cancer. 2010 Feb;20(2):303-7. doi: 10.1111/IGC.0b013e3181cc339c.
To discuss the clinical experiences of aggressive angiomyxoma (AAM) by summarizing clinical information of patients with this disease in China.
Chinese articles concerning AAM were retrospectively reviewed and analyzed.
A total of 93 cases in 44 well-documented articles had been reported, among which 11 were male and 82 were female, with a male to female ratio of 1:7.45. The age of the females varied from 14 to 55 years (mean [SD], 37.17 [10.39] years; median, 38.5 years), whereas that of the males ranged from 15 to 65 years (mean [SD], 44.75 [17.61] years; median, 55 years), which was significantly higher than that of the females (t = 2.082, P = 0.041). The most common sites were the perineum in females and the scrotum in males. None of the cases could be accurately diagnosed as AAM preoperatively. The mean minimum diameter of the tumors was 4.62 (3.51) cm, and the maximum was 9.12 (8.23) cm. All the specimens showed typical pathological features of AAM as reported previously. Immunohistochemistry indicated that AAM tended to be strongly positive for vimentin, smooth-muscle actin, and CD34 but mostly negative for S-100 and CD68. The duration of the postoperative follow-up was 3 to 96 months (mean [SD], 28.5 [18.86] months; median, 9.5 months) in 44 cases, with a recurrence rate of 31.82%.
Aggressive angiomyxoma must be considered in the differential diagnosis of any female with an asymptomatic perineal mass. A complete margin-free excision should be achieved to avoid recurrence. Long-term follow-up is quite necessary because of the high rate of local recurrence.
通过总结中国侵袭性血管黏液瘤（AAM）患者的临床资料，探讨该病的临床特点。
回顾性分析国内报道的 AAM 病例资料。
共检索到 44 篇文献中 93 例 AAM 患者的临床资料，其中男 11 例，女 82 例，男女比例为 1:7.45。女性年龄 14～55 岁，平均（37.17±10.39）岁，中位数为 38.5 岁；男性年龄 15～65 岁，平均（44.75±17.61）岁，中位数为 55 岁，男性年龄显著大于女性（t=2.082，P=0.041）。最常见发病部位为女性的会阴部和男性的阴囊部。术前均未能准确诊断为 AAM。肿瘤最小直径 3.51～9.12cm，平均 4.62cm。所有标本均具有典型的 AAM 病理特征。免疫组化结果显示 AAM 表达波形蛋白、平滑肌肌动蛋白、CD34 的比例较高，而 S-100、CD68 的表达比例较低。44 例患者术后随访 3～96 个月，平均（28.5±18.86）个月，中位数为 9.5 个月，复发率为 31.82%。
对于无症状的会阴部女性包块，应考虑 AAM 的诊断。彻底的边界阴性切除是避免复发的关键。由于局部复发率高，患者需长期随访。
