对映选择性去对称钯催化羰基化反应：含季碳中心的 1,3-二烯的催化不对称合成。
Enantioselective desymmetrizing palladium catalyzed carbonylation reactions: the catalytic asymmetric synthesis of quaternary carbon center containing 1,3-dienes.
机构信息
Department of Chemistry, University of Bath, Bath, UKBA2 7AY.
出版信息
Org Biomol Chem. 2010 Feb 21;8(4):758-60. doi: 10.1039/b923186b. Epub 2009 Dec 21.
DOI:10.1039/b923186b
PMID:20135030
Abstract
A desymmetrization protocol has been used to develop a palladium catalyzed enantioselective carbonylation process. Achiral cyclic bis-alkenyltriflates are converted to their corresponding monoester derivatives with selectivities of up to 96% ee.
摘要
已采用去对称化方法开发了一种钯催化的对映选择性羰基化反应。非手性环状双烯基三氟甲磺酸酯转化为其相应的单酯衍生物，对映选择性高达 96%ee。
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