从羧酸出发，通过简单新颖的方法合成酸叠氮化物、脲和氨基甲酸酯：肽缩合剂 EDC 和 HBTU 的应用。
New and simple synthesis of acid azides, ureas and carbamates from carboxylic acids: application of peptide coupling agents EDC and HBTU.
机构信息
Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore - 560 001, India.
出版信息
Org Biomol Chem. 2010 Feb 21;8(4):835-40. doi: 10.1039/b920290k. Epub 2009 Dec 8.
DOI:10.1039/b920290k
PMID:20135041
Abstract
Conversion of carboxylic acids into acid azides using peptide coupling agents, EDC and HBTU is described. The procedure is efficient, practical and applicable to a diverse range of carboxylic acids including N-protected amino acids. Using the same reagents, one-pot synthesis of ureas, dipeptidyl urea esters and carbamates from acids has also been achieved.
摘要
描述了使用肽偶联试剂 EDC 和 HBTU 将羧酸转化为酸叠氮化物的方法。该方法高效、实用，适用于包括 N-保护氨基酸在内的多种羧酸。使用相同的试剂，还可以从酸中一锅合成脲、二肽基脲酯和氨基甲酸酯。
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