Department of General, Visceral and Transplant Surgery, Tübingen University Hospital, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany.
Surg Endosc. 2010 Aug;24(8):1996-2001. doi: 10.1007/s00464-010-0893-5. Epub 2010 Feb 5.
Obesity is becoming an epidemic health problem and is associated with concomitant diseases, such as sleep apnea syndrome and gastroesophageal reflux disease (GERD). There is no standardized diagnostic workup for the upper gastrointestinal tract in obese patients; many patients have no upper gastrointestinal symptoms, and few data are available on safety of endoscopy in morbidly obese patients.
Sixty-nine consecutive diagnostic upper gastrointestinal endoscopies in morbidly obese patients (26 men, 43 women; mean age 43.4 +/- 10.9 years) were prospectively evaluated from January to December 2008 in an outpatient setting before bariatric procedures. Sedation was administered with propofol. Data on sedation, critical events, and examination times were recorded, as well as pathological findings.
The patients' mean body mass index was 47.6 +/- 7.9 (range, 35.1-73.3) kg/m(2); 17.4% reported GERD symptoms. The mean duration of the endoscopy procedure (including sedation) was 20.3 +/- 9.3 (range, 5-50) min, and the whole procedure (including preparation and postprocessing) took 58.2 +/- 19 (range, 20-120) min. The mean propofol dosage was 380 +/- 150 (range, 80-900) mg. Two patients had critical events that required bronchoscopic intratracheal O(2) insufflation due to severe hypoxemia (<60% SaO: (2)). Nearly 80% of patients had pathological findings in the upper gastrointestinal tract. Only 20% reported upper gastrointestinal symptoms. Pathologic conditions were found in the esophagus in 23.2% of the patients, in the stomach in 78.2%, and in the duodenum in 11.6%. The prevalence of Helicobacter pylori infection was 8.7%.
Upper gastrointestinal endoscopy can be performed safely. However, careful monitoring and anesthesiological support are required for patients with concomitant diseases and those receiving sedation. Because 80% of the patients with pathological findings were asymptomatic, every morbidly obese patient should undergo endoscopy before bariatric surgery because there may be findings that might change the surgical strategy.
肥胖正成为一种流行的健康问题,并与睡眠呼吸暂停综合征和胃食管反流病(GERD)等并存疾病相关。目前,对于肥胖患者的上消化道还没有标准化的诊断方法;许多患者没有上消化道症状,并且很少有关于病态肥胖患者内镜检查安全性的数据。
2008 年 1 月至 12 月,我们在门诊环境下前瞻性评估了 69 例连续进行的诊断性上消化道内镜检查,这些患者为病态肥胖者(26 名男性,43 名女性;平均年龄 43.4 +/- 10.9 岁),这些患者均在接受减肥手术之前进行内镜检查。采用异丙酚进行镇静。记录镇静、危急事件和检查时间的数据,以及病理发现。
患者的平均体重指数为 47.6 +/- 7.9(范围 35.1-73.3)kg/m2;17.4%报告有 GERD 症状。内镜检查的平均持续时间(包括镇静)为 20.3 +/- 9.3(范围 5-50)min,整个过程(包括准备和后处理)耗时 58.2 +/- 19(范围 20-120)min。异丙酚的平均用量为 380 +/- 150(范围 80-900)mg。有 2 例患者出现危急事件,需要支气管镜经气管内 O2 通气,因为严重低氧血症(<60%SaO:(2))。近 80%的患者在上消化道有病理发现。只有 20%的患者报告有上消化道症状。23.2%的患者食管有病理改变,78.2%的患者胃有病理改变,11.6%的患者十二指肠有病理改变。幽门螺杆菌感染的患病率为 8.7%。
上消化道内镜检查是安全的。但是,对于患有并存疾病和接受镇静的患者,需要进行仔细的监测和麻醉支持。由于 80%的有病理发现的患者无症状,因此,在进行减肥手术之前,每个病态肥胖患者都应进行内镜检查,因为可能会发现可能改变手术策略的发现。