Kakisaka Y, Ishitobi M, Wakusawa K, Haginoya K, Togashi N, Kitamura T, Hino-Fukuyo N, Sato I, Uematsu M, Tsuchiya S
Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan.
Neuropediatrics. 2009 Aug;40(4):199-200. doi: 10.1055/s-0029-1241187. Epub 2010 Feb 4.
We have successfully eliminated herpes simplex virus-2 from the central nervous system in a case of neonatal herpes simplex virus encephalitis with a continuous acyclovir infusion. A male infant delivered from a healthy 22-year-old woman without genital or systemic herpes symptoms around delivery began to develop fever and intractable seizures. He was started on intermittent intravenous acyclovir (20 mg/kg every 8 h) based on the diagnosis of herpes encephalitis. The virus was not eliminated with intermittent acyclovir and vidarabine, while continuous acyclovir was ultimately effective in eliminating herpes simplex virus from his central nervous system. This report demonstrates the efficacy of continuous acyclovir infusion in neonatal herpes simplex virus encephalitis.
在一例新生儿单纯疱疹病毒性脑炎患者中，我们通过持续输注阿昔洛韦成功地从其中枢神经系统清除了单纯疱疹病毒2型。一名男婴由一位健康的22岁女性分娩，分娩前后该女性无生殖器或全身性疱疹症状，该男婴开始出现发热和顽固性癫痫发作。基于疱疹性脑炎的诊断，他开始接受间歇性静脉注射阿昔洛韦（每8小时20mg/kg）治疗。间歇性使用阿昔洛韦和阿糖腺苷未能清除病毒，而持续输注阿昔洛韦最终有效地从其中枢神经系统清除了单纯疱疹病毒。本报告证明了持续输注阿昔洛韦治疗新生儿单纯疱疹病毒性脑炎的疗效。
