Münster Michael, Suchodolski Jan S, Bilzer Thomas, Bilzer Claudia, Hörauf Angelika, Steiner Jörg M
Tierärztliche Gemeinschaftspraxis Dr. Hörauf und Dr. Münster, Köln.
Berl Munch Tierarztl Wochenschr. 2010 Jan-Feb;123(1-2):74-82.
The aim of this retrospective study in 40 dogs with chronic inflammatory enteropathies was to investigate a possible influence of immunologic and metabolic deficiencies on the success of dietary treatments. At the time of initial presentation, routine clinical and laboratory methods were used to evaluate various metabolic (i.e., weight loss, measurement of serum total protein, albumin, and cobalamin concentrations) and immunological parameters (i.e., serum globulin concentration, immunoglobulin-fractionation by serum electrophoresis, and serum C-reactive protein concentration as measured by a species-specific ELISA). The dogs were classified as food-responsive (FR-group, n = 11), antibiotic-responsive (AR-group, n = 12), steroid-responsive (SR-group, n = 11), or dogs with various combinations of therapies due to protein-losing enteropathy (PLE-group, n = 6). Differences among the four treatment groups were evaluated by statistical analysis. Compared to dogs in the AR, SR, and PLE groups, dogs in the FR-group showed a significantly milder weight loss (p < 0.01 for each). Dogs in the FR-group also had significantly higher serum concentrations of total protein and albumin compared to the PLE-group (p < 0.001 for each). The FR-group had significantly higher median concentrations of total globulin and gamma-globulin fractions compared to the AR- and PLE-groups (p <0.005 and p < 0.01, respectively). Lower gamma-globulin concentrations correlated with increased weight loss (Spearman r = -0.53; p < 0.005), serum cobalamin (Spearman r = 0.38; p < 0.05), and albumin (Spearman r = 0.45; p < 0.01). Increased serum concentrations of C-reactive protein correlated inversely with serum concentrations of cobalamin (Spearman r = -0.58; p < 0.05) and gamma-globulins (Spearman r = -0.6; p < 0.005). This study provides evidence for a possible association between the severity of immunological disturbances and the development of deficiencies in dogs with chronic enteropathies. This study provides further evidence that less severe physiological disturbances, such as milder forms of weight loss and higher serum concentrations of albumin, globulin, and gamma-globulin are possibly associated with a more favorably response to dietary treatment alone.
这项针对40只患有慢性炎症性肠病的犬只的回顾性研究，旨在调查免疫和代谢缺陷对饮食治疗效果的可能影响。在初次就诊时，采用常规临床和实验室方法评估各种代谢参数（即体重减轻、血清总蛋白、白蛋白和钴胺素浓度的测量）和免疫参数（即血清球蛋白浓度、通过血清电泳进行免疫球蛋白分级，以及通过物种特异性ELISA测量的血清C反应蛋白浓度）。这些犬只被分为食物反应型（FR组，n = 11）、抗生素反应型（AR组，n = 12）、类固醇反应型（SR组，n = 11），或因蛋白丢失性肠病而采用多种治疗组合的犬只（PLE组，n = 6）。通过统计分析评估四个治疗组之间的差异。与AR、SR和PLE组的犬只相比，FR组的犬只体重减轻明显较轻（每组p < 0.01）。与PLE组相比，FR组的犬只血清总蛋白和白蛋白浓度也显著更高（每组p < 0.001）。与AR组和PLE组相比，FR组的总球蛋白和γ-球蛋白组分的中位数浓度显著更高（分别为p <0.005和p < 0.01）。较低的γ-球蛋白浓度与体重减轻增加（Spearman r = -0.53；p < 0.005）、血清钴胺素（Spearman r = 0.38；p < 0.05）和白蛋白（Spearman r = 0.45；p < 0.01）相关。血清C反应蛋白浓度升高与血清钴胺素浓度（Spearman r = -0.58；p < 0.05）和γ-球蛋白浓度（Spearman r = -0.6；p < 0.005）呈负相关。本研究为慢性肠病犬只免疫紊乱的严重程度与缺陷发展之间可能存在关联提供了证据。本研究进一步证明，较轻的生理紊乱，如较轻形式的体重减轻以及血清白蛋白、球蛋白和γ-球蛋白浓度较高，可能与仅饮食治疗的更有利反应相关。
