Ding Hao, Zhang Changqing
Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, PR China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Jan;24(1):112-5.
To summarize the basic research and the clinical use of small intestinal submucosa (SIS), which is used as a degradable material for tissue repair.
Recent literature concerning SIS at home and abroad was extensively reviewed, and current developments of the basic research and the clinical use of SIS were investigated.
SIS had many biological advantages in tissue repair, and was used to repair various tissue defects in animal trials. It had successful outcomes in many clinical trials to repair hernia, anal fistula and Peyronie diseases. And it also had good results at the early stage to treat dilation of the anastomosis, urethroplasty, hypospadias, and other diseases, however, the long-term follow-up was needed.
SIS is one kind of good material for tissue repair, and has promising future in the clinical use.
总结用作组织修复可降解材料的小肠黏膜下层（SIS）的基础研究及临床应用情况。
广泛查阅国内外近期有关SIS的文献，考察SIS基础研究及临床应用的当前进展。
SIS在组织修复方面具有诸多生物学优势，在动物试验中用于修复各种组织缺损。在修复疝、肛瘘和佩罗尼氏病的多项临床试验中取得了成功结果。在治疗吻合口扩张、尿道成形术、尿道下裂等疾病的早期也有良好效果，不过需要长期随访。
SIS是一种良好的组织修复材料，在临床应用中具有广阔前景。
