Boehringer Ingelheim (Canada) Ltd. Research and Development, 2100 rue Cunard, Laval (Québec), Canada H7S 2G5.
J Org Chem. 2010 Mar 5;75(5):1550-60. doi: 10.1021/jo9022793.
A full overview of the decarboxylative cross-coupling reaction between heteroaromatic carboxylic acids and aryl halides is described. This transformation employs palladium catalysts with short reaction times providing facile synthesis of aryl-substituted heteroaromatics. The effect of each reaction parameter including solvent, base, and additive employed as well as the full substrate scope of this transformation are reported. Mechanistic evidence is also disclosed that sheds light on possible reaction pathways.
描述了杂芳基羧酸和芳基卤化物之间的脱羧交叉偶联反应的全面概述。这种转化采用钯催化剂，反应时间短，可方便地合成芳基取代的杂芳烃。报告了每种反应参数（包括溶剂、碱和添加剂）的影响以及该转化的完整底物范围。还披露了有助于阐明可能的反应途径的机理证据。
