Division of Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA.
Tissue Eng Part C Methods. 2010 Oct;16(5):1145-56. doi: 10.1089/ten.TEC.2009.0685.
Convection induced by repetitive compression of porous tissue scaffolds enhances solute transport inside the scaffold. Our previous experiments have shown that pore size, shape, and orientation with respect to strain direction greatly influence loading-induced solute transport. The objective of this study was to develop a computational model of deformation-induced solute transport in porous tissue scaffolds, which included the pore geometry of the scaffold. This geometry consisted of a cubic scaffold with single channel in the middle of the scaffold, immersed in a fluid reservoir. Cylindrical pores with circular or elliptic cross section, and spheroid pores were modeled. The scaffold was cyclically compressed from one side, causing fluid motion and dispersion of solute inside the scaffold pore. Scaffold deformation was solved using the finite element method, and fluid flow and solute transport were solved using the finite volume method. The distortion of the scaffold-fluid interface was transferred as a boundary condition to the fluid flow solver. Both convection and diffusion were included in the computations. The solute transport rates in the different scaffold pore geometries agreed well with our previous experimental results obtained with X-ray microimaging. This model will be used to explore transport properties of a spectrum of novel scaffold designs.
多孔组织支架的反复压缩产生的对流会增强支架内部溶质的传输。我们之前的实验已经表明，孔径、形状和相对于应变方向的取向会极大地影响加载诱导的溶质传输。本研究的目的是开发一种用于多孔组织支架变形诱导的溶质传输的计算模型，该模型包括支架的孔隙几何形状。该几何形状由一个中间有单通道的立方支架组成，浸泡在流体储层中。模拟了具有圆形或椭圆形横截面的圆柱形孔和球形孔。支架从一侧周期性压缩，导致支架孔内流体运动和溶质的弥散。支架变形使用有限元方法求解，流体流动和溶质传输使用有限体积法求解。支架-流体界面的变形作为边界条件传递给流体流动求解器。计算中包括对流和扩散。不同支架孔隙几何形状的溶质传输速率与我们之前使用 X 射线微成像获得的实验结果吻合良好。该模型将用于探索一系列新型支架设计的传输特性。
