Spencer J A, Watson J M, Lubahn D B, Joseph D R, French F S, Wilson E M, Graves J A
Department of Genetics and Human Variation, La Trobe University, Bundoora, Victoria, Australia.
J Hered. 1991 Mar-Apr;82(2):134-9. doi: 10.1093/oxfordjournals.jhered.a111047.
The androgen receptor gene (AR), which is located on the long arm of the human X chromosome, was mapped by somatic cell analysis and in situ hybridization in marsupial and monotreme species. Both methods demonstrated that it was located on the X chromosome in each marsupial species, and also in the platypus. We conclude that this gene is part of a highly conserved region of the mammalian X, represented by the human Xq, which formed part of the X chromosome in a mammalian ancestor 150 million years ago. Since this gene is located proximally on the long arm of the monotreme X, which is G-band homologous to the Y and apparently exempt from X chromosome inactivation, the conservation of this region has evidently not depended on its isolation by X-Y differentiation or on X inactivation.
雄激素受体基因（AR）位于人类X染色体的长臂上，通过体细胞分析和原位杂交技术在有袋类动物和单孔目动物中进行了定位。两种方法均表明，该基因在每个有袋类物种以及鸭嘴兽的X染色体上均有定位。我们得出结论，该基因是哺乳动物X染色体高度保守区域的一部分，以人类Xq为代表，它在1.5亿年前的哺乳动物祖先中就构成了X染色体的一部分。由于该基因位于单孔目动物X染色体长臂的近端，该区域与Y染色体G带同源，且显然不受X染色体失活的影响，因此该区域的保守性显然不依赖于通过X-Y分化或X失活将其隔离。
