新大陆猴雄激素受体中的短聚谷氨酰胺重复序列。
Short poly-glutamine repeat in the androgen receptor in New World monkeys.
作者信息
Hiramatsu Chihiro, Paukner Annika, Kuroshima Hika, Fujita Kazuo, Suomi Stephen J, Inoue-Murayama Miho
机构信息
Department of Human Science, Faculty of Design, Kyushu University, Postal address: 4-9-1 Shiobaru, Minamiku, Fukuoka, 815-8540, Japan.
Physiological Anthropology Research Center, Kyushu University, Postal address: 4-9-1 Shiobaru, Minamiku, Fukuoka, 815-8540, Japan.
出版信息
Meta Gene. 2017 Dec;14:105-113. doi: 10.1016/j.mgene.2017.08.006. Epub 2017 Sep 1.
The androgen receptor mediates various physiological and developmental functions and is highly conserved in mammals. Although great intraspecific length polymorphisms in poly glutamine (poly-Q) and poly glycine (poly-G) regions of the androgen receptor in humans, apes and several Old World monkeys have been reported, little is known about the characteristics of these regions in New World monkeys. In this study, we surveyed 17 species of New World monkeys and found length polymorphisms in these regions in three species (common squirrel monkeys, tufted capuchin monkeys and owl monkeys). We found that the poly-Q region in New World monkeys is relatively shorter than that in catarrhines (humans, apes and Old World monkeys). In addition, we observed that codon usage for poly-G region in New World monkeys is unique among primates. These results suggest that the length of polymorphic regions in androgen receptor genes have evolved uniquely in New World monkeys.
雄激素受体介导多种生理和发育功能，在哺乳动物中高度保守。尽管已有报道称人类、猿类和几种旧世界猴的雄激素受体的聚谷氨酰胺（poly-Q）和聚甘氨酸（poly-G）区域存在较大的种内长度多态性，但对于新世界猴中这些区域的特征却知之甚少。在本研究中，我们调查了17种新世界猴，发现其中三种（普通松鼠猴、簇绒卷尾猴和夜猴）的这些区域存在长度多态性。我们发现新世界猴的poly-Q区域比狭鼻猴类（人类、猿类和旧世界猴）的相对短。此外，我们观察到新世界猴中poly-G区域的密码子使用在灵长类中是独特的。这些结果表明雄激素受体基因多态区域的长度在新世界猴中经历了独特的进化。
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