Department of Public Health, School of Public Health and Health Sciences, University of Massachusetts-Amherst, Amherst, MA 01003, USA.
Nutr Rev. 2010 Feb;68(2):122-8. doi: 10.1111/j.1753-4887.2009.00268.x.
Several mechanistic studies in cell culture and mouse models suggest possible estrogen receptor-mediated and non-estrogen receptor-mediated benefits of pomegranate juice with respect to breast cancer risk. These studies demonstrate that various constituents of pomegranates can inhibit aromatase and 17beta-hydroxysteroid dehydrogenase enzymes or have antiestrogenic activity. Additional large, well-controlled human studies are warranted to elucidate the effects of pomegranate juice intake on serum hormone levels. Clarifying the effects of pomegranate constituents on key hormones known to be involved in breast cancer could result in important information for consumers and shed further light on the impact of diet on breast cancer risk.
几项细胞培养和小鼠模型的机制研究表明，石榴汁可能通过雌激素受体和非雌激素受体途径对乳腺癌风险产生有益影响。这些研究表明，石榴的各种成分可以抑制芳香酶和 17β-羟类固醇脱氢酶，或具有抗雌激素活性。需要进行更多大型、对照良好的人体研究，以阐明石榴汁摄入对血清激素水平的影响。阐明石榴成分对已知参与乳腺癌的关键激素的影响，可能为消费者提供重要信息，并进一步阐明饮食对乳腺癌风险的影响。
