[中长链脂肪酸甘油三酯可降低超重和高甘油三酯血症患者的体脂和血清甘油三酯水平]

[Medium- and long-chain fatty acid triacylglycerol reduce body fat and serum triglyceride in overweight and hypertriglyceridemic subjects].

作者信息

Zhang Yue-hong, Liu Ying-hua, Zheng Zi-xin, Wang Jin, Zhang Yong, Zhang Rong-xin, Yu Xiao-ming, Jing Hong-jiang, Xue Chang-yong, Wu Jian

机构信息

Department of Nutrition, Chinese People's Liberation Army of General Hospital, Beijing, China.

出版信息

Zhonghua Yu Fang Yi Xue Za Zhi. 2009 Sep;43(9):765-71.

PMID:20137557

Abstract

OBJECTIVE

To investigate effects of medium- and long-chain fatty acid triacylglycerols (MLCT) on body fat and serum lipid in overweight and hypertriglyceridemic subjects.

METHODS

A double-blind, controlled clinical trial was carried out, in which 112 subjects with hypertriglyceridemia were enrolled and divided into two groups, there were 56 subjects in each group. One group was randomized to consume long-chain fatty acid triacylglycerol (LCT), and the other to MLCT. All volunteers were asked to consume 25 - 30 g test oil daily for consecutive 8 weeks. Anthropometric measurements of body weight, body fat weight, waist circumference(WC), hip circumference(HC), WHR (ratio of WC/HC), total fat weight, subcutaneous fat area, visceral fat area, and serum biochemical variables of glucose, total cholesterols(TC), triglycerides(TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C)were measured at the initial and final time of the study.

RESULTS

11 subjects were excluded from the study because of various reasons. Of the 101 included cases, there were 50 (male subject 34, 68.0%) and 51 (male subject 33, 64.7%) subjects left in LCT and MLCT group respectively. The proportion of men in MLCT (64.7%, 33/51) was not significantly different (chi(2) = 0.1227, P > 0.05) compared to those in LCT (68.0%, 34/50). The average age of MLCT was (54.2 +/- 12.5) which was not significantly different (t = 0.39, P > 0.05) compared to those in LCT (53.2 +/- 13.0); Body mass index (BMI) of MLCT was (25.9 +/- 3.3) kg/m(2), which was not significantly different (t = 0.08, P > 0.05) compared to those of LCT (25.9 +/- 2.4) kg/m(2). After consumption of test oil for 8 weeks, extent of decrease in BMI, percent of body fat, subcutaneous fat, serum TG and serum LDL-C in overweight subjects of MLCT were (-0.73 +/- 0.61) kg/m(2), (-1.53 +/- 1.32)%, (-16.29 +/- 19.25) cm(2), (-0.57 +/- 0.86) mmol/L and (-0.05 +/- 0.64) mmol/L respectively, those in overweight subjects of LCT were (-0.19 +/- 0.61) kg/m(2), (-0.58 +/- 1.02)%, (4.69 +/- 19.06) cm(2), (0.65 +/- 1.10) mmol/L and (0.38 +/- 0.58) mmol/L respectively, all of them were significantly different (the value of t were -2.70, -2.43, -3.20, -3.81 and -2.09 respectively, all of P value were less than 0.05).

CONCLUSION

Consumption of MLCT can reduce body fat weight and serum triacylglycerol and LDL-C in overweight hypertriglyceridemic subjects under an appropriate dietary regime.

摘要

目的

探讨中长链脂肪酸甘油三酯（MLCT）对超重及高甘油三酯血症患者体脂和血脂的影响。

方法

进行一项双盲对照临床试验，纳入112例高甘油三酯血症患者并分为两组，每组56例。一组随机食用长链脂肪酸甘油三酯（LCT），另一组食用MLCT。所有志愿者连续8周每天食用25 - 30 g试验油。在研究开始和结束时测量体重、体脂重量、腰围（WC）、臀围（HC）、腰臀比（WHR，WC/HC比值）、总脂肪重量、皮下脂肪面积、内脏脂肪面积等人体测量指标，以及血糖、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）等血清生化指标。

结果

11例患者因各种原因被排除出研究。在纳入的101例病例中，LCT组和MLCT组分别有50例（男性34例占68.0%）和51例（男性33例占64.7%）。MLCT组男性比例（64.7%，33/51）与LCT组（68.0%，34/50）相比差异无统计学意义（χ² = 0.1227，P > 0.05）。MLCT组平均年龄为（54.2 ± 12.5）岁，与LCT组（53.2 ± 13.0）相比差异无统计学意义（t = 0.39，P > 0.05）；MLCT组体重指数（BMI）为（25.9 ± 3.3）kg/m²，与LCT组（25.9 ± 2.4）kg/m²相比差异无统计学意义（t = 0.08，P > 0.05）。食用试验油8周后，MLCT组超重患者的BMI降低幅度、体脂百分比、皮下脂肪、血清TG和血清LDL-C分别为（-0.73 ± 0.61）kg/m²、（-1.53 ± 1.32）%、（-16.29 ± 19.25）cm²、（-0.57 ± 0.86）mmol/L和（-0.05 ± 0.64）mmol/L，LCT组超重患者分别为（-0.19 ± 0.61）kg/m²、（-0.58 ± 1.02）%、（4.69 ± 19.06）cm²、（0.65 ± 1.10）mmol/L和（0.38 ± 0.58）mmol/L，差异均有统计学意义（t值分别为-2.70、-2.43、-3.20、-3.81和-2.09，P值均小于0.05）。