Department of Gerontology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Chin Med J (Engl). 2010 Jan 5;123(1):89-94.
A general review was made of studies involving: (1) the relationship between sleep apnea hypopnea syndrome/sleep apnea style intermittent hypoxia and liver injury and (2) the mechanism that causes the liver injury.
The data used in this review were mainly from Medline and PubMed published in English from 1993 to February 2009. The search term was "sleep apnea hypopnea syndrome".
(1) Clinical and laboratory evidence that sleep apnea hypopnea syndrome and sleep apnea style intermittent hypoxia leads to liver injury; (2) the mechanism that causes the liver injury.
The effect of sleep apnea hypopnea syndrome and sleep apnea style intermittent hypoxia on the liver function is characterized by serum aminotransferase elevation. The liver histological injury includes hepatic steatosis, hepatocyte ballooning, lobular inflammation, lobular necrosis, and liver fibrosis. Sleep apnea hypopnea syndrome and sleep apnea style intermittent hypoxia can cause insulin resistance and oxidative stress.
Sleep apnea hypopnea syndrome and sleep apnea style intermittent hypoxia can lead to chronic liver injury, which, in most cases, is shown as nonalcoholic fatty liver disease. Insulin resistance and oxidative stress caused by sleep apnea hypopnea syndrome and sleep apnea style intermittent hypoxia play an important role in the mechanism of chronic liver disease development.
对涉及以下两个方面的研究进行综述：（1）睡眠呼吸暂停低通气综合征/睡眠呼吸暂停样间歇性低氧与肝损伤的关系，以及（2）导致肝损伤的机制。
本综述中使用的数据主要来源于 Medline 和 PubMed 数据库中 1993 年至 2009 年 2 月期间以英文发表的资料，检索词为“睡眠呼吸暂停低通气综合征”。
（1）有临床和实验室证据表明睡眠呼吸暂停低通气综合征和睡眠呼吸暂停样间歇性低氧可导致肝损伤；（2）导致肝损伤的机制。
睡眠呼吸暂停低通气综合征和睡眠呼吸暂停样间歇性低氧对肝功能的影响表现为血清转氨酶升高。肝组织学损伤包括肝脂肪变性、肝细胞气球样变、小叶炎症、小叶坏死和肝纤维化。睡眠呼吸暂停低通气综合征和睡眠呼吸暂停样间歇性低氧可导致胰岛素抵抗和氧化应激。
睡眠呼吸暂停低通气综合征和睡眠呼吸暂停样间歇性低氧可导致慢性肝损伤，在大多数情况下表现为非酒精性脂肪性肝病。睡眠呼吸暂停低通气综合征和睡眠呼吸暂停样间歇性低氧引起的胰岛素抵抗和氧化应激在慢性肝病发展的机制中起重要作用。
