Yang Xi-lin, Liu Xiao-hong, Ke Mei-yun, Song Zhi-qiang, Yuan Yao-zong, Luo Jin-yan, Hou Xiao-hua
Department of Gastroenterology, PUMC Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
Zhonghua Yi Xue Za Zhi. 2009 Sep 15;89(34):2404-7.
To investigate the longitudinal changes in quality of life (QoL) for gastroesophageal reflux disease (GERD) treated with 52-week rabeprazole over a period of 2-3 years.
A multi-center, open-label and randomized 52-week rabeprazole trial was conducted in 67 eosinophilic esophagitis (EE) and 31 non-erosive reflux disease (NERD) patients. The follow-up period is 2-3 years after the treatment. Their QoL were evaluated using SF-36 Health Survey Questionnaire and GERD-HRQL scale. The results were compared with those acquired before and after a 52-week proton pump inhibitor (PPI) treatment.
(1) Both EE and NERD patients improved significantly according to GERD-HRQL scale in scores of reflux symptoms as well as overall satisfaction (12.5 vs 3.5, 20.0 vs 14.0, both P < 0.01) versus the pre-therapy baseline. (2) Both EE and NERD patients had no significant difference in the scale of GERD-HRQL (2.0 vs 3.5, 5.0 vs 4.0, both P > 0.05) and most major domains of SF-36 questionnaire versus the post-therapy baseline (53 +/- 17 vs 61 +/- 17, t = -2.143, P = 0.035). (3) The NERD patients had a higher score of reflux symptoms than the EE patients according to the GERD-HRQL Scale (14.0 vs 3.5, Z = 2.377, P = 0.017), however there were no significant differences between NERD and EE in 8 major domains of SF-36 questionnaire (P > 0.05).
Long-term and low-dose PPI treatment achieves improvement both in reflux symptoms and QoL in GERD patients and such effects last a long time. At follow-ups, the reflux symptoms of NERD patients are more severe than EE patients. However, the overall QoL has shown little differences between these two subtypes.
研究接受52周雷贝拉唑治疗的胃食管反流病（GERD）患者在2至3年期间生活质量（QoL）的纵向变化。
对67例嗜酸性食管炎（EE）患者和31例非糜烂性反流病（NERD）患者进行了一项多中心、开放标签的随机52周雷贝拉唑试验。随访期为治疗后2至3年。使用SF-36健康调查问卷和GERD-HRQL量表评估他们的生活质量。将结果与52周质子泵抑制剂（PPI）治疗前后获得的结果进行比较。
（1）与治疗前基线相比，EE和NERD患者在GERD-HRQL量表上的反流症状评分以及总体满意度均显著改善（分别为12.5对3.5、20.0对14.0，P均<0.01）。（2）与治疗后基线相比，EE和NERD患者在GERD-HRQL量表上（分别为2.0对3.5、5.0对4.0，P均>0.05）以及SF-36问卷的大多数主要领域均无显著差异（53±17对61±17，t=-2.143，P=0.035）。（3）根据GERD-HRQL量表，NERD患者的反流症状评分高于EE患者（14.0对3.5，Z=2.377，P=0.017），然而在SF-36问卷的8个主要领域中，NERD和EE之间无显著差异（P>0.05）。
长期低剂量PPI治疗可改善GERD患者的反流症状和生活质量，且这种效果持续时间较长。在随访中，NERD患者的反流症状比EE患者更严重。然而，这两种亚型之间的总体生活质量差异不大。
