The Procter & Gamble Company, Brussels Innovation Center, Strombeek-Bever, Belgium.
Dermatitis. 2010 Jan-Feb;21(1):8-32.
Development, evaluation and validation of alternatives to skin sensitisation testing require the availability of reliable databases with which comparative analyses can be conducted to establish performance characteristics. To facilitate this we have published previously a database comprising results from local lymph node assays (LLNAs) conducted with 211 chemicals. That database embraced a substantial range of chemistry, and of relative skin sensitising potency, and has found application in the assessment of new or refined methods.
In this paper we describe a second compilation to extend the LLNA database.
This second data compilation was derived from previously conducted LLNA studies involving an additional 108 chemicals. In addition, the first database contained a small number of inaccuracies, affecting results recorded with a few chemicals. In this paper these have been corrected.
The inclusion of 108 new substances has served to extend and consolidate the areas of chemistry covered by the database. In addition, the entire dataset was evaluated for pre and prohaptens which will facilitate the choice of chemicals for alternative assay developments.
It is anticipated that the new revised and extended database totalling over 300 chemicals will now serve as the primary resource to support the development and evaluation of new approaches to hazard identification and potency assessment.
替代皮肤致敏测试的开发、评估和验证需要有可靠的数据库，以便进行比较分析，以确定性能特征。为了促进这一点，我们之前已经发布了一个数据库，其中包含了 211 种化学品的局部淋巴结检测（LLNA）的结果。该数据库涵盖了广泛的化学物质和相对皮肤致敏效力，并已应用于新方法或改进方法的评估。
本文描述了第二个数据库编译，以扩展 LLNA 数据库。
这第二个数据编译是从之前进行的 LLNA 研究中得出的，涉及另外 108 种化学品。此外，第一个数据库中包含一些不准确的信息，影响了少数化学品的记录结果。在本文中，这些已经得到了纠正。
包含 108 种新物质，扩展和巩固了数据库涵盖的化学领域。此外，整个数据集都针对前和原敏物质进行了评估，这将有助于选择用于替代检测开发的化学品。
预计新修订和扩展的数据库，共包含超过 300 种化学品，现在将作为支持新方法开发和评估以识别危害和评估效力的主要资源。
