Division of Small Animal Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan.
Res Vet Sci. 2010 Aug;89(1):124-5. doi: 10.1016/j.rvsc.2009.12.018.
The effect of fluconazole (Fcz) on the cyclosporine (CsA) dosage was investigated in renal transplanted dogs receiving CsA-based immunosuppressive therapy. Initially, CsA was administered orally twice daily to raise the blood trough level between 400 and 600 ng/ml. After the addition of Fcz, the CsA dosage was adjusted to maintain its therapeutic blood concentration. Fcz significantly decreased CsA dosage in both normal and renal transplanted dogs, but a higher dosage of CsA was needed in renal transplanted dogs. In conclusion, Fcz decreases required CsA dosage and thereby reduces the cost of immunosuppressive therapy in canine renal transplantation.
本研究旨在探讨氟康唑（Fcz）对肾移植犬环孢素（CsA）剂量的影响。研究中，肾移植犬接受以 CsA 为基础的免疫抑制治疗，首先每日口服 CsA 两次，以将血药谷浓度维持在 400-600ng/ml 之间。在加用 Fcz 后，调整 CsA 剂量以维持其治疗血药浓度。结果显示，Fcz 可显著降低正常犬和肾移植犬的 CsA 剂量，但肾移植犬需要更高的 CsA 剂量。结论：Fcz 降低了所需 CsA 剂量，从而降低了犬肾移植免疫抑制治疗的成本。
