糖尿病犬作为人类胰岛移植的转化模型
The Diabetic Dog as a Translational Model for Human Islet Transplantation.
作者信息
Adin Christopher A, Gilor Chen
机构信息
Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC.
Department of Medicine and Epidemiology, College of Veterinary Medicine, University of California, Davis, CA.
出版信息
Yale J Biol Med. 2017 Sep 25;90(3):509-515. eCollection 2017 Sep.
Abstract
The dog model has served as the primary method for early development of many diabetes therapies, including pancreatic islet transplantation techniques and immunosuppressive protocols. Recent trends towards the use of monoclonal antibody therapies for immunosuppression in human islet transplantation have led to the increasing use of primate models with induced diabetes. In addition to induced-disease models in large animals, scientists in many fields are considering the use of naturally-occurring disease models in client-owned pets. This article will review the applicability of naturally-occurring diabetes in dogs as a translational model for developing islet transplantation in the human diabetic patient.
摘要
犬类模型一直是许多糖尿病治疗方法早期研发的主要手段，包括胰岛移植技术和免疫抑制方案。近期，在人类胰岛移植中使用单克隆抗体疗法进行免疫抑制的趋势，使得诱导糖尿病灵长类动物模型的使用日益增加。除了大型动物的诱导疾病模型外，许多领域的科学家都在考虑使用宠物身上自然发生的疾病模型。本文将综述犬类自然发生的糖尿病作为人类糖尿病患者胰岛移植研发的转化模型的适用性。
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