腹内侧前额叶神经激肽 1 受体的可利用性在慢性疼痛中降低。
Ventromedial prefrontal neurokinin 1 receptor availability is reduced in chronic pain.
机构信息
Department of Psychology, Uppsala University, Uppsala, Sweden Uppsala Imanet AB, GE Healthcare, Uppsala, Sweden Department of Physiotherapy, School of Health, Care and Social Welfare, Mälardalen University, Västerås, Sweden Section of Physiotherapy, Department of Neuroscience, Uppsala University, Sweden Laboratory of Pain Research, Department of Surgical Sciences, Division of Anaesthesiology and Intensive Care Medicine, Uppsala University Hospital, Sweden Department of Biochemistry and Organic Chemistry, Uppsala University, Sweden Neuropsychopharmacology Section, Faculty of Medicine, Imperial College, London, UK.
出版信息
Pain. 2010 Apr;149(1):64-70. doi: 10.1016/j.pain.2010.01.008. Epub 2010 Feb 4.
Neurokinin 1 (NK1) receptors are involved in pain and anxiety behaviors in animals, but little is known about central alterations in this receptor system in human pain. With positron emission tomography, using a [11]-Carbon labeled NK1 receptor antagonist, we demonstrate attenuated NK1 receptor availability in frontal, insular and cingulate cortex, as well as the hippocampus, amygdala and the periaqueductal gray area in patients with chronic pain. The reduced availability was most pronounced in the ventromedial prefrontal cortex (vmPFC), where attenuations correlated to measures of fear and avoidance of movement. Further, vmPFC NK1 levels also displayed opposing influences in patients as compared to controls on regional cerebral blood flow in the anterior cingulate. We conclude that the central NK1 receptor system is altered in human chronic pain. The results suggest that NK1 receptors in the vmPFC modulate motor inhibition, and contribute to fear and avoidance of movement.
神经激肽 1（NK1）受体参与动物的疼痛和焦虑行为，但对于人类疼痛中该受体系统的中枢变化知之甚少。我们使用正电子发射断层扫描（PET），使用 [11]-碳标记的 NK1 受体拮抗剂，证明慢性疼痛患者的额皮质、岛叶和扣带回皮质以及海马体、杏仁核和导水管周围灰质区域的 NK1 受体可用性降低。在腹内侧前额皮质（vmPFC）中，这种减少最为明显，其中衰减与恐惧和运动回避的测量值相关。此外，与对照组相比，vmPFC NK1 水平在慢性疼痛患者中对前扣带的局部脑血流也有相反的影响。我们得出结论，人类慢性疼痛中中枢 NK1 受体系统发生了改变。研究结果表明，vmPFC 中的 NK1 受体调节运动抑制，并有助于对运动的恐惧和回避。
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