Drug Alcohol Depend. 2010 Jun 1;109(1-3):1-3; author reply 4-5. doi: 10.1016/j.drugalcdep.2010.01.002.
Moxnes and Jensen (2009) present a study of decision making under conditions of uncertainty using a computerised simulation of alcohol pharmacokinetics. In their article, they conclude that their findings challenge the 'folk wisdom' that advises against drinking on an empty stomach. We contend that this is a problematic conclusion for three reasons: (1) the study and findings presented in their paper are simply not sufficient to allow one to, even tentatively, draw such a conclusion; (2) the conclusion is contrary to basic pharmacological knowledge concerning alcohol absorption, metabolism and the implications for peak blood alcohol concentration; and (3) the implications for understanding the process of decision making while alcohol intoxicated are not considered in the study. The Moxnes and Jensen (2009) study did not involve alcohol administration and is therefore an examination of decision making in situations of uncertainty rather than a specific exploration of drinking-related decision making. Recent formulations of the effects of alcohol on cognitive processing would lead to different conclusions than those presented by Moxnes and Jensen (2009). We conclude by suggesting our understanding of the implications of the study.
莫克内斯和延森（2009）使用酒精药代动力学的计算机模拟，展示了一项在不确定条件下进行决策的研究。在他们的文章中，他们得出结论，他们的发现挑战了“民间智慧”，即不建议空腹饮酒。我们认为，这是一个有问题的结论，原因有三：（1）他们在论文中提出的研究和发现，根本不足以让人，甚至是试探性地，得出这样的结论；（2）该结论与关于酒精吸收、代谢以及对血液酒精浓度峰值的影响的基本药理学知识相悖；（3）在研究中没有考虑到理解醉酒状态下决策过程的含义。莫克内斯和延森（2009）的研究并没有涉及酒精的使用，因此，这是对不确定性情况下决策的研究，而不是对与饮酒相关的决策的具体探索。最近对酒精对认知加工的影响的表述会得出与莫克内斯和延森（2009）不同的结论。我们最后提出了对这项研究的理解。
