Department of Molecular Cytogenetics, Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 1 Str., 05-552 Wolka Kosowska, Poland.
Physiol Behav. 2010 Apr 19;99(5):627-31. doi: 10.1016/j.physbeh.2010.01.023. Epub 2010 Feb 4.
Considering the involvement of the opioid system in alcoholism, depression and metabolism - known risk factors in human obesity, we studied the effects of chronic mild stress (CMS) and alcohol intake on body weight in two mouse lines selected for high (HA-high analgesia) or low (LA-low analgesia) swim stress-induced analgesia. In comparison to LA mice, HA mice exhibit an upregulation of opioid receptor system function, different depression-like behavior and reduced energy expenditure in stress. LA animals showed enhanced basal and CMS-induced alcohol drinking versus HA. Now we report different effects of alcohol under no stress (control) and CMS conditions on food intake and body weight between the lines. CMS in animals with no access to alcohol increased body weight in both HA and LA mice, with no effect of CMS on food intake in either line and without differences between the lines. In LA mice alcohol reduced body weight under both conditions although significantly more under the control than CMS conditions. In contrast, in HA mice alcohol increased body weight more under the CMS than under control conditions. The results suggest that opioid system may modulate effects of alcohol on stress -induced changes in body weight.
考虑到阿片系统在酗酒、抑郁和新陈代谢中的作用——这些都是人类肥胖的已知风险因素，我们研究了慢性轻度应激（CMS）和酒精摄入对两种选择用于高（HA-高镇痛）或低（LA-低镇痛）游泳应激诱导镇痛的小鼠品系体重的影响。与 LA 小鼠相比，HA 小鼠表现出阿片受体系统功能上调、不同的抑郁样行为和应激时能量消耗减少。与 HA 相比，LA 动物表现出增强的基础和 CMS 诱导的酒精摄入。现在我们报告了在没有应激（对照）和 CMS 条件下，酒精对两条品系的食物摄入和体重的不同影响。在没有酒精摄入的情况下，CMS 增加了 HA 和 LA 小鼠的体重，CMS 对两条品系的食物摄入都没有影响，两条品系之间也没有差异。在 LA 小鼠中，酒精在两种情况下都减轻了体重，尽管在对照条件下比 CMS 条件下更显著。相比之下，在 HA 小鼠中，CMS 下酒精对体重的影响大于对照条件下。结果表明，阿片系统可能调节酒精对压力引起的体重变化的影响。
