Dowd M T, Chen C T, Wendel M J, Faulhaber P J, Cooper M D
University of Chicago, Department of Radiology, Illinois 60637.
J Nucl Med. 1991 Apr;32(4):707-12.
Accurate determination of the radiation dose to the bladder wall from 2-[18F]fluoro-2-deoxy-D-glucose (2-[18F]FDG) is important because the bladder is the critical organ in radiotracer studies using 2-[18F]FDG. The radiation dose to the bladder wall from injected 2-[18F]FDG was estimated using both a dynamic bladder model and the conventional MIRD model. The dynamic model takes into account the excretion rate, the varying size of the bladder, the volume at injection, and an estimated bladder time activity curve. Our data from 302 adult subjects in a five-year period indicate that when the bladder is large at the time of injection, the dose to the bladder is greatly reduced. The absorbed dose of the bladder based on the dynamic model for an initial volume of 450 ml is 0.16 +/- 0.06 rad/mCi, while that for an initial volume of 200 ml is calculated to be 0.37 +/- 0.18 rad/mCi. The MIRD model estimates an average value of 0.35 +/- 0.16 rad/mCi for the 302 cases.
准确测定膀胱壁对2-[¹⁸F]氟-2-脱氧-D-葡萄糖（2-[¹⁸F]FDG）的辐射剂量很重要，因为在使用2-[¹⁸F]FDG的放射性示踪剂研究中，膀胱是关键器官。使用动态膀胱模型和传统的MIRD模型估计了注入的2-[¹⁸F]FDG对膀胱壁的辐射剂量。动态模型考虑了排泄率、膀胱大小的变化、注射时的体积以及估计的膀胱时间-活度曲线。我们在五年期间对302名成年受试者的数据表明，注射时膀胱较大时，膀胱所受剂量会大幅降低。基于动态模型，初始体积为450 ml时膀胱的吸收剂量为0.16±0.06 rad/mCi，而初始体积为200 ml时计算得出为0.37±0.18 rad/mCi。MIRD模型对这302例病例估计的平均值为0.35±0.16 rad/mCi。
