Vodafone Foundation Institute and Chair for Children's Pain Therapy and Paediatric Palliative Care (VIKP), Witten/Herdecke University, Children's Hospital Datteln, Germany Center for Child Neurology, Witten/Herdecke University, Children's Hospital Datteln, Germany Department of Pain Management, Berufsgenossenschaftliche Universitätsklinik Bergmannsheil GmbH, Ruhr University Bochum, Germany Department of Neurophysiology, Medizinische Fakultät Mannheim der Universität Heidelberg, Germany.
Pain. 2010 Apr;149(1):76-88. doi: 10.1016/j.pain.2010.01.011. Epub 2010 Feb 6.
The Quantitative Sensory Testing (QST) protocol of the German research network on neuropathic pain (DFNS) encompassing all somatosensory modalities assesses the functioning of different nerve fibers and of central pathways. The aim of our study was: (1) to explore, whether this QST protocol is feasible for children, (2) to detect distribution properties of QST data and the impact of body site, age and gender and (3) to establish reference values for QST in children and adolescents. The QST protocol of the DFNS with modification of instructions and pain rating was used in 176 children aged 6.12-16.12years for six body sites. QST was feasible for children over 5years of age. ANOVAs revealed developmental, gender and body site differences of somatosensory functions similar to adults. The face was more sensitive than the hand and/or foot. Younger children (6-8years) were generally less sensitive to all thermal and mechanical detection stimuli but more sensitive to all pain stimuli than older (9-12years) children, whereas there were little differences between older children and adolescents (13-17years). Girls were more sensitive to thermal detection and pain stimuli, but not to mechanical detection and pain stimuli. Reference values differ from adults, but distribution properties (range, variance, and side differences) were similar and plausible for statistical factors. Our results demonstrate that the full QST protocol is feasible and valid for children over 5years of age with their own reference values.
定量感觉测试（QST）方案的德国研究网络的神经性疼痛（DFNS）涵盖所有躯体感觉方式评估不同的神经纤维和中枢通路的功能。我们的研究目的是：（1）探讨该 QST 方案是否适用于儿童，（2）检测 QST 数据的分布特性以及身体部位、年龄和性别对其的影响，（3）为儿童和青少年建立 QST 的参考值。DFNS 的 QST 方案经过修改后的说明和疼痛评分在 176 名年龄为 6.12-16.12 岁的儿童的六个身体部位进行了测试。QST 对 5 岁以上的儿童是可行的。方差分析显示，躯体感觉功能的发育、性别和身体部位差异与成人相似。面部比手和/或脚更敏感。年龄较小的儿童（6-8 岁）对所有热和机械探测刺激通常不太敏感，但对所有疼痛刺激比年龄较大的儿童（9-12 岁）更敏感，而年龄较大的儿童和青少年（13-17 岁）之间几乎没有差异。女孩对热探测和疼痛刺激更敏感，但对机械探测和疼痛刺激不敏感。参考值与成人不同，但分布特性（范围、方差和侧面差异）对于统计因素来说是相似且合理的。我们的研究结果表明，完整的 QST 方案对于 5 岁以上的儿童是可行和有效的，且有其自己的参考值。
