Department of Anatomy and Cell Biology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa, Nagoya, Aichi 466-8550, Japan.
Curr Opin Neurobiol. 2010 Feb;20(1):22-8. doi: 10.1016/j.conb.2010.01.001.
Cortical development progresses through an early phase of progenitor expansion, a middle phase of neurogenesis, and a final phase of gliogenesis. During the middle phase, the neurogenic phase, the neocortical primordium balances the production of neurons against the maintenance of neural precursor cells (NPCs). The final number of neurons is determined by the duration of the neurogenic phase, the rate of NPC division, and the mode of NPC division, that is, whether a division gives rise to two NPCs, one NPC and one cell committed to the neuronal lineage, or two committed cells. We discuss here recent advances in understanding these key aspects that are fundamental for normal brain development.
皮质发育经过早期祖细胞扩增阶段、中期神经发生阶段和晚期神经胶质发生阶段。在中期神经发生阶段，皮质原始层平衡神经元的产生和神经前体细胞（NPC）的维持。神经元的最终数量取决于神经发生阶段的持续时间、NPC 分裂的速度以及 NPC 分裂的方式，即分裂产生两个 NPC、一个 NPC 和一个向神经元谱系分化的细胞，还是两个分化细胞。本文讨论了在理解这些对正常大脑发育至关重要的关键方面的最新进展。
