Department of Psychology, University of British Columbia, 2136 West Mall, Vancouver, British Columbia, Canada V6T1Z4.
Neurosci Lett. 2010 Mar 26;472(3):171-4. doi: 10.1016/j.neulet.2010.01.079. Epub 2010 Feb 4.
In the present study, sexual behavior of male rats was assessed following prolonged treatment with the CB(1) receptor agonist, HU-210 (0.1mg/mg/day for 10 days) under conditions of drug maintenance, spontaneous withdrawal and precipitated withdrawal (induced via administration of the CB(1) receptor antagonist AM251; 1mg/kg). Following subchronic cannabinoid treatment, sexual activity in male rats was impaired under both the drug maintenance and spontaneous withdrawal conditions, as revealed by a reduction in frequency of both intromissions and ejaculations. Notably, the induction of precipitated drug withdrawal reversed the negative effects of subchronic HU-210 treatment on sexual activity as seen by a reversal of the suppression of ejaculations. These data illustrate that, contrary to expectations, the impairments in male sexual activity following protracted cannabinoid administration are not due to drug withdrawal, per se, but are likely mediated by neuroadaptive changes provoked by repeated drug exposure.
在本研究中，在药物维持、自发戒断和催瘾戒断（通过给予 CB1 受体拮抗剂 AM251[1mg/kg]诱导）条件下，雄性大鼠在接受 CB1 受体激动剂 HU-210（0.1mg/mg/天，持续 10 天）的长期治疗后，其性行为得到了评估。在慢性大麻素治疗后，无论是在药物维持还是自发戒断条件下，雄性大鼠的性行为都受到损害，这表现为插入和射精的频率均减少。值得注意的是，催瘾性药物戒断的诱导逆转了亚慢性 HU-210 治疗对性行为的负面影响，因为射精的抑制得到了逆转。这些数据表明，与预期相反，在长期给予大麻素后雄性性行为的损伤并不是由于药物戒断本身引起的，而是可能是由反复药物暴露引起的神经适应性变化介导的。
