Aljurf Mahmoud, Nassar Amr, Saleh Abu J, Almhareb Fahed, Alzahrani Hazzaa, Walter Claudia, Bakr Mohammad, Ahmed Syed Osman, Chaudhri Naeem
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Hematol Oncol Stem Cell Ther. 2009;2(3):399-402. doi: 10.1016/s1658-3876(09)50008-8.
Acute lymphoblastic leukemia (ALL) is a relatively rare disease during pregnancy, accounting for about 15% of all cases of pregnancy-associated leukemia. Although mixed lineage leukemia gene (MLL) rearrangement is the dominant genetic aberration in infantile acute leukemia, the occurrence of MLL gene rearrangement in maternal ALL occurring during pregnancy has not been reported. Out of 31 cases of maternal leukemia diagnosed during pregnancy at our institution, 5 were ALL cases. Three of the 5 patients had MLL gene rearrangement. The data for these 5 patients are presented in this report. We believe that the association of MLL gene rearrangement with maternal leukemia is biologically plausible and this observation needs to be validated in a larger cohort of pregnancy-associated maternal leukemia cases.
急性淋巴细胞白血病（ALL）在孕期相对罕见，约占所有妊娠相关白血病病例的15%。尽管混合谱系白血病基因（MLL）重排是婴儿急性白血病的主要遗传畸变，但孕期发生的母源性ALL中MLL基因重排的情况尚未见报道。在我们机构诊断的31例孕期母源性白血病病例中，有5例为ALL病例。这5例患者中有3例发生了MLL基因重排。本报告展示了这5例患者的数据。我们认为MLL基因重排与母源性白血病之间的关联在生物学上是合理的，这一观察结果需要在更大规模的妊娠相关母源性白血病病例队列中得到验证。
