DNA 烷化损伤修复系统在沙门氏菌毒力中的相关性。
Relevance of DNA alkylation damage repair systems in Salmonella enterica virulence.
机构信息
Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Bellaterra, Spain.
出版信息
J Bacteriol. 2010 Apr;192(7):2006-8. doi: 10.1128/JB.01693-09. Epub 2010 Feb 5.
Abstract
Systematic inactivation of pathways involved in DNA alkylation damage repair demonstrated that inactivation of the ada, ogt, tag, uvrA, and mfd genes is required to detect a Salmonella enterica virulence decrease. Furthermore, the fitness of S. enterica, defective in these genes, is lowered only when the bacterium is orally, but not intraperitoneally, inoculated.
摘要
系统失活涉及 DNA 烷化损伤修复的途径表明，需要失活 ada、ogt、tag、uvrA 和 mfd 基因才能检测到沙门氏菌毒力下降。此外，这些基因缺陷的沙门氏菌的适应性仅在细菌经口服而非腹腔内接种时降低。
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