Key Lab for Oral Biomedical Engineering of Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, Hubei, 430079, P.R. China.
J Dent Res. 2010 Apr;89(4):366-71. doi: 10.1177/0022034509358822. Epub 2010 Feb 5.
Alveolar bone loss is one of the prominent pathologic and clinical features of periodontitis. Recently, the direct effect of follicle-stimulating hormone (FSH) on bone resorption has been demonstrated. However, the effect of FSH on alveolar bone loss remains unknown. This study tested the hypothesis that FSH would exacerbate periodontitis-related alveolar bone loss. Experimental periodontitis was induced in ovariectomized rats, and the rats were treated with extrinsic FSH or its inhibitor, leuprorelin. After mandibles were collected, we performed morphological examinations to evaluate bone loss, enzyme histochemical tests for osteoclasts, and immunohistochemical examinations for FSH receptor (FSHR). The results showed that FSH significantly increased alveolar bone resorption compared with non-FSH-treated ovariectomized rats (P < 0.05), and the number of FSHR-positive cells was positively correlated with alveolar bone loss area (r = 0.682, P < 0.01). Our results suggested that FSH can aggravate alveolar bone loss by FSHR, independent of estrogen.
牙槽骨丧失是牙周炎的主要病理和临床特征之一。最近，已经证明了卵泡刺激素 (FSH) 对骨吸收的直接作用。然而，FSH 对牙槽骨丧失的影响尚不清楚。本研究检验了 FSH 会加重与牙周炎相关的牙槽骨丧失这一假设。在去卵巢大鼠中诱导实验性牙周炎，并对大鼠进行外源性 FSH 或其抑制剂亮丙瑞林治疗。收集下颌骨后，我们进行形态学检查以评估骨丢失、破骨细胞的酶组织化学测试和 FSH 受体 (FSHR) 的免疫组织化学检查。结果表明，与未用 FSH 治疗的去卵巢大鼠相比，FSH 显著增加了牙槽骨吸收 (P<0.05)，并且 FSHR 阳性细胞的数量与牙槽骨丧失面积呈正相关 (r=0.682，P<0.01)。我们的结果表明，FSH 可以通过 FSHR 加重牙槽骨丧失，而与雌激素无关。
