Ajayi A O, Ajayi E A, Fasakin K A
Department of Medicine, Federal Medical Centre, PMB 201, Ido-Ekiti, Nigeria.
Ann Afr Med. 2009 Oct-Dec;8(4):257-60. doi: 10.4103/1596-3519.59581.
To evaluate the CD4+ cell counts in adults with human immunodeficiency virus (HIV) infections presenting at the medical department of the Federal Medical Centre, Ido-Ekiti, Nigeria.
This study was carried out at the medical department of the Federal Medical Centre (FMC), Ido-Ekiti, Nigeria, in the period July-December 2006. FMC, Ido, was recently upgraded to serve as the only center for HIV/AIDS referral, diagnosis and treatment in Ekiti State. The center offers free antiretroviral therapy. All patients with a diagnosis of HIV/AIDS, either diagnosed at the center or referred from other hospitals, admitted to the medical department within the study period had their blood sample taken for CD4 cell counts estimation at the first visit to the center, as part of the routine workup to assess their disease status and need for antiretroviral therapy.
A total of 87 patients comprising of 54 (62.1%) females and 33 (37.9%) males had their CD4+ T-Lymphocytes cell counts evaluated within their first week of presentation. The total mean age of the population studied was 33.17 +/- 7.01 years. The mean age of the females was 31 +/- 5.6 years, while that of the males was 36.5 +/- 8.2 years. The difference between the mean ages of females and males was statistically significant (P = 0.0004). The female: male ratio was 1.6:1. Out of the 87 patients, 30 were referrals from other hospitals within the state. The total mean CD4+ cell count was 230.7 +/- 311.9 cells/microL. The mean CD4 cell count of females was 212.17 +/- 264.96 cells/microL, while that of males was 261.0 +/- 389.19 cells/microL. This difference was not significant (P = 0.4876). Majority of the patients (75, [86.2%]), had CD4 cell count < 350 cells/microL, comprising of 48 females and 27 males. Of the 75 patients, 57 (76%) had a CD4 cell count < 200 cells/microL (33 females vs. 24 males).
At the time of HIV diagnosis, majority of our patients had a CD4+ cell count < 200 cells/microL. This was consistent with a relatively advanced disease. More women than men in the population were found positive for HIV. More sustained and vigorous awareness campaigns need be embarked upon in the HIV propaganda in the Ekiti State on one hand and Nigeria on the other hand to bring down this Hydra-headed monster called HIV/AIDS.
评估在尼日利亚伊多-埃基蒂联邦医疗中心内科就诊的成年人类免疫缺陷病毒（HIV）感染者的CD4+细胞计数。
本研究于2006年7月至12月在尼日利亚伊多-埃基蒂联邦医疗中心内科进行。伊多的联邦医疗中心最近升级为埃基蒂州唯一的HIV/AIDS转诊、诊断和治疗中心。该中心提供免费抗逆转录病毒治疗。所有在研究期间被诊断为HIV/AIDS的患者，无论是在该中心确诊还是从其他医院转诊而来，在内科就诊时均采集血样进行CD4细胞计数评估，作为评估其疾病状态和抗逆转录病毒治疗需求的常规检查的一部分。
共有87例患者，其中女性54例（62.1%），男性33例（37.9%），在就诊第一周内进行了CD4+T淋巴细胞计数评估。研究人群的总平均年龄为33.17±7.01岁。女性平均年龄为31±5.6岁，男性为36.5±8.2岁。女性和男性平均年龄的差异具有统计学意义（P = 0.0004）。女性与男性的比例为1.6:1。87例患者中，30例是该州其他医院的转诊患者。CD4+细胞计数的总平均值为230.7±311.9个/微升。女性的平均CD4细胞计数为212.17±264.96个/微升，男性为261.0±389.19个/微升。这种差异不显著（P = 0.4876）。大多数患者（75例，[86.2%]）的CD4细胞计数<350个/微升，其中女性48例，男性27例。在这75例患者中，57例（76%）的CD4细胞计数<200个/微升（女性33例，男性24例）。
在HIV诊断时，我们的大多数患者CD4+细胞计数<200个/微升。这与疾病相对晚期一致。该人群中HIV检测呈阳性的女性多于男性。一方面在埃基蒂州，另一方面在尼日利亚，需要开展更持续、有力的艾滋病宣传活动，以战胜这个被称为HIV/AIDS的多头怪物。
