University of Cologne, Institute of Virology, Cologne, Germany.
AIDS. 2010 Mar 13;24(5):779-81. doi: 10.1097/QAD.0b013e328336784d.
Recently, first-line lopinavir failure was observed due to protease mutation 76V. In the present study, we found 76V associated with protease mutation 46I and gag cleavage-site mutation 431V. Longitudinal analysis of patients failing protease inhibitor therapies demonstrated that 76V strictly occurs either together with 46I and/or 431V or in HIV isolates already harbouring one of both mutations. Therefore, all three mutations seem to cooperate in terms of protease inhibitor resistance.
最近，由于蛋白酶突变 76V，观察到一线洛匹那韦失效。在本研究中，我们发现与蛋白酶突变 46I 和 gag 切割位点突变 431V 相关的 76V。对失败于蛋白酶抑制剂治疗的患者进行的纵向分析表明，76V 严格地与 46I 和/或 431V 一起出现，或者出现在已经携带其中一种突变的 HIV 分离物中。因此，所有这三种突变似乎在蛋白酶抑制剂耐药方面具有协同作用。
