Xia Bin, Liu Ke-ying, Wang Chun-li, Sun Li-jun, Ge Li-hong
Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2010 Feb 18;42(1):78-81.
To assess the safety, effectiveness and acceptability of oral midazolam sedation for dental treatment in children.
Twenty-three health children aged 4 to 14 (ASA I), who were classified as 4 or 5 by modified Venham's clinic anxiety and cooperative behavior rating scale, referred for dental treatment were included in the study. Each child was treated under sedation with oral midazolam (0.15-0.70 mg/kg), and totally 45 sedations were conducted. At each visit, heart rate, arterial oxygen saturation, respiration rate, sedation and behavioral scores were recorded. The level of acceptance and satisfaction of the patients and their guardians were recorded after the treatment.
Among the 23 children, 19 were boys and 4 were girls with mean age of 6.2 years old. In all the 45 treatments, the heart rate, respiratory rate and arterial oxygen saturation levels were within acceptable clinical limits. Forty planned treatments were completed satisfactorily. Oral sedation was ineffective in 3 children, and they were treated under general anesthesia. Only 2 guardians refused to have oral midazolam sedation again. Six of seven children who had regular dental check-up could be treated under normal condition.
Oral midazolam (0.15-0.70 mg/kg) could be a safe and acceptable approach of sedation for pediatric dental patients.
评估口服咪达唑仑用于儿童牙科治疗镇静的安全性、有效性和可接受性。
本研究纳入23名4至14岁的健康儿童（ASA I级），这些儿童因改良的韦纳姆临床焦虑和合作行为评分量表评定为4级或5级而需接受牙科治疗。每名儿童接受口服咪达唑仑（0.15 - 0.70 mg/kg）镇静治疗，共进行了45次镇静。每次就诊时记录心率、动脉血氧饱和度、呼吸频率、镇静和行为评分。治疗后记录患者及其监护人的接受程度和满意度。
23名儿童中，19名男孩，4名女孩，平均年龄6.2岁。在所有45次治疗中，心率、呼吸频率和动脉血氧饱和度水平均在可接受的临床范围内。40项计划治疗圆满完成。3名儿童口服镇静无效，改在全身麻醉下治疗。只有2名监护人拒绝再次接受口服咪达唑仑镇静。7名定期进行口腔检查的儿童中有6名能够在正常情况下接受治疗。
口服咪达唑仑（0.15 - 0.70 mg/kg）对儿童牙科患者可能是一种安全且可接受的镇静方法。
