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抑郁症状与处于精神病超高风险人群中的脑代谢物改变：一项初步研究。

Depressive Symptoms and Brain Metabolite Alterations in Subjects at Ultra-high Risk for Psychosis: A Preliminary Study.

机构信息

Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.

出版信息

Psychiatry Investig. 2009 Dec;6(4):264-71. doi: 10.4306/pi.2009.6.4.264. Epub 2009 Nov 21.

DOI:10.4306/pi.2009.6.4.264
PMID:20140124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2808795/
Abstract

OBJECTIVE

Recent neuroimaging studies have suggested that brain changes occur in subjects at ultra-high risk (UHR) for psychosis while experiencing prodromal symptoms, among which depression may increase the risk of developing a psychotic disorder. The goal of this study is to examine brain metabolite levels in the anterior cingulate cortex, the left dorsolateral prefrontal cortex and the left thalamus in subjects at UHR for psychosis and to compare brain metabolite levels between the UHR subjects with comorbid major depressive disorder and healthy controls.

METHODS

Proton magnetic resonance spectroscopy was used to examine brain metabolite levels. Twenty UHR subjects and 20 age- and intelligence quotient (IQ)-matched healthy controls were included in this study.

RESULTS

Overall, no significant differences were observed in any metabolite between the UHR and healthy control group. However, UHR subjects with major depressive disorder showed significantly higher myo-inositol (Ins) levels in the left thalamus, compared to the healthy control.

CONCLUSION

Our results demonstrate that increased thalamic Ins level is associated with prodromal depressive symptoms. Further longitudinal follow-up studies with larger UHR sample sizes are required to investigate the function of Ins concentrations as a biomarker of vulnerability to psychosis.

摘要

目的

最近的神经影像学研究表明，处于精神病超高风险（UHR）的个体在经历前驱症状时大脑会发生变化，其中抑郁可能会增加患精神病的风险。本研究旨在检查 UHR 精神病患者前扣带回皮质、左侧背外侧前额叶皮质和左侧丘脑的脑代谢物水平，并比较 UHR 伴发重性抑郁障碍患者与健康对照者之间的脑代谢物水平。

方法

采用质子磁共振波谱法检查脑代谢物水平。本研究纳入 20 名 UHR 患者和 20 名年龄和智商（IQ）匹配的健康对照者。

结果

总体而言，UHR 组和健康对照组之间任何代谢物均无显著差异。然而，与健康对照组相比，UHR 伴重性抑郁障碍患者左侧丘脑的肌醇（Ins）水平显著升高。

结论

我们的结果表明，前扣带回皮质、左侧背外侧前额叶皮质和左侧丘脑的脑代谢物水平升高与前驱期抑郁症状有关。需要进一步进行更大规模 UHR 样本量的纵向随访研究，以探讨 Ins 浓度作为精神病易感性生物标志物的功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0820/2808795/61330997097b/pi-6-264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0820/2808795/a9748f1cf8a2/pi-6-264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0820/2808795/61330997097b/pi-6-264-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0820/2808795/a9748f1cf8a2/pi-6-264-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0820/2808795/61330997097b/pi-6-264-g002.jpg

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