黑果腺肋花楸果汁对大鼠的抗焦虑样作用。
Anxiolytic-like effect of Aronia melanocarpa fruit juice in rats.
作者信息
Valcheva-Kuzmanova S, Zhelyazkova-Savova M
机构信息
Department of Preclinical and Clinical Pharmacology and Toxicology, Medical University, Varna, Bulgaria.
出版信息
Methods Find Exp Clin Pharmacol. 2009 Dec;31(10):651-4. doi: 10.1358/mf.2009.31.10.1423884.
The main biologically active constituents of Aronia melanocarpa fruit juice (AMFJ) are polyphenolics, amongst them flavonoids, mainly anthocyanins. The aim of the present study was to investigate the effects of AMFJ (5 and 10 mL/kg) on anxiety using the social interaction test, on locomotor activity in the open field test and on working memory in the object recognition test in rats. AMFJ showed an anxiolytic-like effect which was demonstrated by a dose-dependent increase in the time of active social contacts between the test partners. The effects of both AMFJ doses were comparable to the effect of diazepam (1 mg/kg). AMFJ neither changed significantly horizontal and vertical locomotor activity, nor did it adversely affect working memory.
黑果腺肋花楸果汁（AMFJ）的主要生物活性成分是多酚类物质，其中包括黄酮类化合物，主要是花青素。本研究的目的是使用社交互动测试来研究AMFJ（5和10 mL/kg）对大鼠焦虑的影响，使用旷场试验研究其对运动活动的影响，并使用物体识别测试研究其对工作记忆的影响。AMFJ表现出抗焦虑样作用，这通过测试伙伴之间主动社交接触时间的剂量依赖性增加得到证明。两种AMFJ剂量的效果与地西泮（1 mg/kg）的效果相当。AMFJ既没有显著改变水平和垂直运动活动，也没有对工作记忆产生不利影响。
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