Moreno Claudia, Troncoso Mercedes, Coria De La Paulina, Ledermann Walter, Del Valle Gladys, Nuñez Cecilia, Araya Pamela, Fernández Jorge, Fernández Alda
Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Rev Chilena Infectol. 2010 Feb;27(1):40-4. Epub 2010 Feb 3.
The gram-negative bacillus Hafnia alvei is the only species of the genus Hafnia, family Enterobacteriaceae. It occasionally behaves as an opportunistic pathogen in humans, causing intestinal and respiratory infection and sepsis. It rarely causes bacteremia, usually of unknown focus.
To describe a nosocomial outbreak of four pediatric patients with bacteremia by Hafnia alvei.
Descriptive study using clinical records of pediatric patients diagnosed with Hafnia alvei bacteremia in a pediatric cardio surgical unit, in October 2008.
The attack rate was 4/8 (50%), lethality rate 2/4 (50%) and mortality 2/8 (25%). The microbiological study and pulsed-field gel electrophoresis confirmed the same clonal bacterial strain.
The source of bacteremia was identified only in two patients and was associated with central venous catheters. The other two cases had no known infectious source. Epidemiological surveillance of emerging agents must be maintained.
革兰氏阴性杆菌蜂房哈夫尼亚菌是肠杆菌科哈夫尼亚菌属的唯一物种。它偶尔会在人类中作为机会致病菌，引起肠道和呼吸道感染以及败血症。它很少引起菌血症，通常感染源不明。
描述一起由蜂房哈夫尼亚菌引起的4例儿科患者医院内菌血症暴发。
采用2008年10月在一家儿科心脏外科病房诊断为蜂房哈夫尼亚菌菌血症的儿科患者的临床记录进行描述性研究。
发病率为4/8（50%），致死率为2/4（50%），死亡率为2/8（25%）。微生物学研究和脉冲场凝胶电泳证实为同一克隆菌株。
仅在2例患者中确定了菌血症的来源，且与中心静脉导管有关。另外2例病例没有已知的感染源。必须持续对新出现的病原体进行流行病学监测。
