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Olanzapine and pancytopenia with severe folate deficiency.

作者信息

Maurier F, Petitpain N, Guichard J-F, Javot L, Tréchot P

出版信息

Eur J Clin Pharmacol. 2010 May;66(5):531-3. doi: 10.1007/s00228-010-0788-3. Epub 2010 Feb 6.

DOI:10.1007/s00228-010-0788-3
PMID:20140427
Abstract
摘要

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Olanzapine and pancytopenia with severe folate deficiency.
Eur J Clin Pharmacol. 2010 May;66(5):531-3. doi: 10.1007/s00228-010-0788-3. Epub 2010 Feb 6.
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Severe pancytopenia due to acute folate deficiency despite normal folate erythrocyte level.尽管红细胞叶酸水平正常，但急性叶酸缺乏仍导致严重全血细胞减少。
Ann Biol Clin (Paris). 2016 Jun 1;74(3):313-6. doi: 10.1684/abc.2016.1137.
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Drug-induced severe sideroblastic anemia following combined olanzapine and fluvoxamine therapy: a case report.奥氮平与氟伏沙明联合治疗后药物性严重铁粒幼细胞贫血：一例报告
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Olanzapine-Induced Thrombocytopenia in a Patient With Chronic Schizophrenia: A Case Report.奥氮平致慢性精神分裂症患者血小板减少症1例报告
Cureus. 2024 Nov 28;16(11):e74677. doi: 10.7759/cureus.74677. eCollection 2024 Nov.
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Thrombocytopenia associated with olanzapine: A case report and review of literature.

本文引用的文献

1
Hyperhomocysteinemia in epileptic patients on new antiepileptic drugs.新抗癫痫药物治疗的癫痫患者的高同型半胱氨酸血症。
Epilepsia. 2010 Feb;51(2):274-9. doi: 10.1111/j.1528-1167.2009.02303.x. Epub 2009 Sep 22.
2
Cough mixture abuse as a novel cause of folate deficiency: a prospective, community-based, controlled study.止咳合剂滥用作为叶酸缺乏的新原因：一项基于社区的前瞻性对照研究。
Haematologica. 2007 Apr;92(4):562-3. doi: 10.3324/haematol.10859.
3
In vitro toxicity of clozapine, olanzapine, and quetiapine on granulocyte-macrophage progenitors (GM-CFU).
奥氮平相关血小板减少症：一例病例报告及文献综述
Indian J Psychiatry. 2016 Jul-Sep;58(3):339-341. doi: 10.4103/0019-5545.192005.
4
Olanzapine-associated leukopenia and thrombocytopenia managed with lithium in a patient who developed leukopenia with clozapine in the past: a case report.奥氮平相关白细胞减少症和血小板减少症，在一名既往使用氯氮平出现白细胞减少症的患者中用锂治疗：病例报告
Prim Care Companion CNS Disord. 2012;14(6). doi: 10.4088/PCC.12l01367.
氯氮平、奥氮平和喹硫平对粒-巨噬细胞祖细胞（GM-CFU）的体外毒性。
Pharmacopsychiatry. 2006 Jan;39(1):20-2. doi: 10.1055/s-2006-931475.
4
Thrombocytopenia and fatality associated with olanzapine.
Eur J Clin Pharmacol. 2004 Jun;60(4):295-6. doi: 10.1007/s00228-004-0772-x. Epub 2004 May 19.
5
Olanzapine-induced agranulocytosis: a case report and review of the literature.奥氮平所致粒细胞缺乏症：一例病例报告及文献复习
Prog Neuropsychopharmacol Biol Psychiatry. 2002 Feb;26(2):411-4. doi: 10.1016/s0278-5846(01)00258-5.
6
One further case of pancytopenia induced by olanzapine in a Parkinson's disease patient.
Eur Neurol. 2001;45(1):56-7. doi: 10.1159/000052093.
7
Thrombocytopenia possibly associated with olanzapine and subsequently with benztropine mesylate.
Psychosomatics. 2000 May-Jun;41(3):277-8. doi: 10.1176/appi.psy.41.3.277.
8
Olanzapine-induced thrombocytopenia in association with idiopathic thrombocytopenic purpura.奥氮平所致血小板减少症合并特发性血小板减少性紫癜。
Br J Psychiatry. 1998 Oct;173:352. doi: 10.1192/bjp.173.4.352a.
9
Prolongation of clozapine-induced granulocytopenia associated with olanzapine.氯氮平所致粒细胞减少症与奥氮平相关的病程延长。
J Clin Psychopharmacol. 1997 Dec;17(6):494-5. doi: 10.1097/00004714-199712000-00014.
10
Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells.氯氮平被活化的人类中性粒细胞氧化成一种反应性氮鎓离子，该离子会与细胞不可逆地结合。
J Pharmacol Exp Ther. 1995 Dec;275(3):1476-83.