黏膜佐剂免疫诱导小鼠产生针对乙型流感病毒的保护和交叉保护免疫应答。
Stimulation of protective and cross-protective immunity against influenza B virus after adjuvant mucosal immunization of mice.
机构信息
Institute of Immunology and Microbiology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
出版信息
Folia Microbiol (Praha). 2009 Nov;54(6):549-52. doi: 10.1007/s12223-009-0080-z. Epub 2010 Feb 7.
PMID:20140725
Abstract
Intratracheal immunization of mice with inactivated influenza B virus and delipidated Bacillus firmus as adjuvant increases protection of mice against infection with the homologous virus strain and induces cross-protection: mice immunized by influenza virus B/Yamanashi 166/98 were protected even against phylogenetically distant virus drift variant B/Lee/40 lethal for mice.
摘要
以灭活的乙型流感病毒和去脂 Firmus 芽孢杆菌作为佐剂对小鼠进行气管内免疫，可增强对同源病毒株感染的保护作用，并诱导交叉保护：用乙型流感病毒 B/Yamanashi 166/98 免疫的小鼠甚至可预防对小鼠具有致死性的亲缘关系较远的病毒漂移变异株 B/Lee/40。
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