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Enhanced systemic and mucosal antibody responses to a model protein antigen after intranasal and intratracheal immunisation using Bacillus firmus as an adjuvant.

作者信息

Mlcková P, Cechová D, Chalupná P, Novotná O, Prokesová L

机构信息

Charles University, First Faculty of Medicine, Institute of Clinical Immunology, Studnickova7, Prague 2 12800, Czech Republic.

出版信息

Immunol Lett. 2001 May 1;77(1):39-45. doi: 10.1016/s0165-2478(01)00192-4.

DOI:10.1016/s0165-2478(01)00192-4
PMID:11348668
Abstract

Bacillus firmus, a non-pathogenic Gram positive (G+) bacterium of the external environment was investigated for immunomodulatory properties. It stimulated an increase in anti-ovalbumin IgG in sera, bronchoalveolar lavages and intestinal washings after both intranasal (i.n.) and intratracheal (i.t.) immunisation, and enhanced anti-ovalbumin IgA in intestinal secretions and in bronchoalveolar lavage fluid after i.n. or i.t. immunisation, respectively. The immunomodulatory effect of B. firmus on antibody formation was antigen specific.

摘要

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