调控秀丽隐杆线虫 DAF-16/FOXO 的多种输入信号的整合。
Integration of diverse inputs in the regulation of Caenorhabditis elegans DAF-16/FOXO.
机构信息
Department of Molecular Biology, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.
出版信息
Dev Dyn. 2010 May;239(5):1405-12. doi: 10.1002/dvdy.22244.
Abstract
In a remarkably conserved insulin signaling pathway that is well-known for its regulation of longevity in worms, flies, and mammals, the major C. elegans effector of this pathway, DAF-16/FOXO, also modulates many other physiological processes. This raises the question of how DAF-16/FOXO chooses the correct targets to achieve the appropriate response in a particular context. Here, we review current knowledge of tissue-specificity and interacting partners that modulate DAF-16/FOXO functional output.
摘要
在一个高度保守的胰岛素信号通路中，该通路以其对蠕虫、苍蝇和哺乳动物寿命的调节而闻名，该通路的主要秀丽隐杆线虫效应物 DAF-16/FOXO 也调节许多其他生理过程。这就提出了一个问题，即 DAF-16/FOXO 如何选择正确的靶标，以在特定环境中实现适当的反应。在这里，我们回顾了组织特异性和调节 DAF-16/FOXO 功能输出的相互作用伙伴的现有知识。
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