利用秀丽隐杆线虫理解不对称细胞分裂在癌症中的作用。

Understanding the role of asymmetric cell division in cancer using C. elegans.

机构信息

Laboratory of Cell Division and Differentiation, Department of Pathology and Cell Biology, Institute of Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Quebec, Canada.

出版信息

Dev Dyn. 2010 May;239(5):1378-87. doi: 10.1002/dvdy.22237.

DOI:10.1002/dvdy.22237

PMID:20140912

Abstract

Asymmetric cell division is an important process to generate cell diversity and maintain tissue homeostasis. Recent evidence suggests that this process may also be crucial to prevent tumor formation. In the past 30 years, the embryo of the nematode Caenorhabditis elegans has proven to be a very powerful model to study the molecular and cellular basis of asymmetric cell division. Understanding this process in Caenorhabditis elegans may thus lead to a better understanding of stem cell function and tumorigenesis in humans.

摘要

不对称细胞分裂是产生细胞多样性和维持组织内稳态的重要过程。最近的证据表明，这一过程对于防止肿瘤形成也可能至关重要。在过去的 30 年中，秀丽隐杆线虫的胚胎已被证明是研究不对称细胞分裂的分子和细胞基础的非常强大的模型。因此，了解秀丽隐杆线虫中的这一过程可能有助于更好地理解人类中的干细胞功能和肿瘤发生。