Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY 14642, United States. jacques
Dev Comp Immunol. 2010 Sep;34(9):915-25. doi: 10.1016/j.dci.2010.05.011. Epub 2010 Jun 2.
Despite intense study in mammals, the different roles played by the immune system in detecting (immunosurveillance), controlling and remodeling (immunoediting) neoplasia, and perhaps in metastasis are not fully understood. In this review, I will present evidence of neoplasia and invasive malignancy, as well as tumor immunity in invertebrates and nonmammalian vertebrates. I will also present a comparative and evolutionary view of the complex interactions between neoplasia and the host immune system. Overall, I wish to go beyond the too simplistic dichotomy between invertebrates with innate immunity that are only affected with benign neoplasia and vertebrates with adaptive immunity that are affected by metastatic malignancies or cancer.
尽管在哺乳动物方面进行了深入研究，但免疫系统在检测（免疫监视）、控制和重塑（免疫编辑）肿瘤，以及在转移中可能发挥的不同作用仍未被完全理解。在这篇综述中，我将介绍无脊椎动物和非哺乳动物脊椎动物中的肿瘤发生和侵袭性恶性肿瘤以及肿瘤免疫的证据。我还将提出一种比较和进化的观点，探讨肿瘤与宿主免疫系统之间复杂的相互作用。总的来说，我希望超越无脊椎动物具有先天免疫，仅受良性肿瘤影响，而脊椎动物具有适应性免疫，易受转移性恶性肿瘤或癌症影响的过于简单的二分法。
