Sainath S B, Reddy P Sreenivasula
Department of Biotechnology, Sri Venkateswara University, Tirupati, Andhra pradesh, India.
J Exp Zool A Ecol Genet Physiol. 2010 Apr 1;313(4):201-8. doi: 10.1002/jez.594.
In this study, the hyperglycemic effect of melatonin in the freshwater edible crab, Oziotelphusa senex senex, is investigated. Injection of melatonin induced hyperglycemia in a dose-dependent manner. Administration of melatonin produced hyperglycemia in both intact and eyestalk-ablated crabs. Bilateral eyestalk ablation resulted in significant increase in the total carbohydrates and glycogen levels with a significant decrease in phosphorylase activity in the hepatopancreas and muscle of the crabs. Injection of melatonin resulted in significant decrease in the total carbohydrate and glycogen levels, with an increase in phosphorylase activity in hepatopancreas and muscle of both intact and eyestalk-ablated crabs. From the results, it is hypothesized that melatonin-induced hyperglycemia in the crab, O. senex senex, is not mediated by eyestalk hyperglycemic hormone.
在本研究中，对褪黑素在淡水食用蟹（Oziotelphusa senex senex）中的高血糖作用进行了研究。注射褪黑素以剂量依赖的方式诱导高血糖。褪黑素给药在完整和眼柄切除的蟹中均产生高血糖。双侧眼柄切除导致蟹的肝胰腺和肌肉中总碳水化合物和糖原水平显著增加，同时磷酸化酶活性显著降低。注射褪黑素导致完整和眼柄切除的蟹的肝胰腺和肌肉中总碳水化合物和糖原水平显著降低，同时磷酸化酶活性增加。根据结果推测，褪黑素诱导的O. senex senex蟹高血糖不是由眼柄高血糖激素介导的。
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