Freund Wolfgang, Wunderlich Arthur P, Stuber Gregor, Landwehrmeyer Bernhard, Klug Roland
Department of Diagnostic and Interventional Radiology, University Hospital, Ulm, Germany.
Somatosens Mot Res. 2010;27(1):15-27. doi: 10.3109/08990220903516593.
Pain can result from various sensory input modalities. To elucidate the differences of cortical responses to graded electrical and thermal stimulation, functional magnetic resonance imaging (fMRI) results of two studies using the same stimulation paradigms but different modalities with 15 healthy subjects each are compared. During painful electrical stimulation contralateral dorsal posterior insula and ventral posterior anterior cingulate cortex (ACC) activated more. During thermal stimulation, there was more activation in ipsilateral primary motor area (MI)/primary sensory area (SI) complex and premotor areas as well as dorsal posterior ACC. Thus electrostimulation preferably activates structures of the lateral pain projection system resulting in contralateral dorsal posterior insula and ventral posterior ACC activation. During thermal stimulation, more dorsal areas of the posterior ACC activated. The activation of ipsilateral MI/SI complex and premotor areas may be attributed to the slower perception of thermal stimuli and resulting re-evaluation. This has to be taken into account in the interpretation of other cross-modality studies as well.
疼痛可由多种感觉输入方式引起。为阐明皮质对分级电刺激和热刺激反应的差异，对两项研究的功能磁共振成像（fMRI）结果进行了比较，这两项研究采用相同的刺激范式，但分别使用不同的刺激方式，每项研究有15名健康受试者。在疼痛性电刺激期间，对侧背侧后岛叶和腹侧后扣带回皮质（ACC）激活更强。在热刺激期间，同侧初级运动区（MI）/初级感觉区（SI）复合体、运动前区以及背侧后ACC有更多激活。因此，电刺激优先激活外侧疼痛投射系统的结构，导致对侧背侧后岛叶和腹侧后ACC激活。在热刺激期间，后ACC的更多背侧区域被激活。同侧MI/SI复合体和运动前区的激活可能归因于对热刺激的较慢感知以及由此产生的重新评估。在解释其他跨模态研究时也必须考虑到这一点。
