Division of Biological Sciences, Tucker Hall, University of Missouri, Columbia, MO 65211, USA.
Biochem J. 2010 Feb 9;426(2):119-23. doi: 10.1042/BJ20091617.
Aneuploidy involves changes in chromosomal copy number compared with normal euploid genotypes. Studies of gene expression in aneuploids in a variety of species have claimed many different types of responses. Studies of individual genes suggest that there are both structural gene dosage effects and compensation in aneuploids, and that subtle trans-acting effects across the genome are quite prevalent. A discussion is presented concerning the normalization procedures for studying gene expression in aneuploids. A careful documentation of the modulations of gene expression in aneuploids should provide insight into the nature of cancerous cells and the basis of aneuploid syndromes.
非整倍体涉及染色体拷贝数与正常整倍体基因型的变化。在多种物种中对非整倍体的基因表达研究声称有许多不同类型的反应。对个别基因的研究表明，非整倍体既有结构基因剂量效应，也有补偿作用，而且基因组中存在普遍的微妙的反式作用效应。本文讨论了研究非整倍体基因表达的归一化程序。仔细记录非整倍体基因表达的调节应该能够深入了解癌细胞的性质和非整倍体综合征的基础。
