Atopy (Allergy) Research Center, Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
Int J Immunogenet. 2010 Apr;37(2):139-41. doi: 10.1111/j.1744-313X.2010.00901.x. Epub 2010 Feb 5.
Two promoter polymorphisms of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha) gene (FCER1A), -66T>C (rs2251746) and -315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the -315CT/TT genotype tended to have higher total serum IgE levels, while the proportion of -315CT/TT genotype or the -315T allele was significantly higher in those with highly elevated total serum IgE concentrations.
两个高亲和力 IgE 受体 alpha 亚基（FcepsilonRIalpha）基因（FCER1A）的启动子多态性，-66T>C（rs2251746）和-315C>T（rs2427827），在日本特应性皮炎患者中进行了分析。-315CT/TT 基因型患者的总血清 IgE 水平较高，而高总血清 IgE 浓度患者的-315CT/TT 基因型或-315T 等位基因的比例显著更高。
