日本特应性皮炎患者 FcepsilonRIalpha 基因（FCER1A）启动子多态性与总血清 IgE 水平。
FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients.
机构信息
Atopy (Allergy) Research Center, Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
出版信息
Int J Immunogenet. 2010 Apr;37(2):139-41. doi: 10.1111/j.1744-313X.2010.00901.x. Epub 2010 Feb 5.
Two promoter polymorphisms of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha) gene (FCER1A), -66T>C (rs2251746) and -315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the -315CT/TT genotype tended to have higher total serum IgE levels, while the proportion of -315CT/TT genotype or the -315T allele was significantly higher in those with highly elevated total serum IgE concentrations.
两个高亲和力 IgE 受体 alpha 亚基（FcepsilonRIalpha）基因（FCER1A）的启动子多态性，-66T>C（rs2251746）和-315C>T（rs2427827），在日本特应性皮炎患者中进行了分析。-315CT/TT 基因型患者的总血清 IgE 水平较高，而高总血清 IgE 浓度患者的-315CT/TT 基因型或-315T 等位基因的比例显著更高。
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