Division of Research, Institute of Tuberculosis, 309 Hospital, Beijing, China.
Int J Immunogenet. 2010 Apr;37(2):97-101. doi: 10.1111/j.1744-313X.2010.00897.x. Epub 2010 Feb 5.
AKT1, a serine/threonine kinase, plays a critical role in the controlling of intracellular growth of Mycobacterium tuberculosis. In this study, we investigated whether polymorphisms in AKT1 affect susceptibility to tuberculosis (TB). Two single nucleotide polymorphisms of AKT1, IVS3+18C>T and +726G>A were genotyped in Chinese patients with pulmonary TB by polymerase chain reaction-restriction fragment length polymorphism. Patients with pulmonary TB had significantly lower IVS3+18 C/C genotype and higher C/T genotype compared with age-, gender- and ethnically matched controls (P < 0.05). The T-A haplotype frequency was significantly higher in patients than in controls (P < 0.05). In conclusion, our result indicates that AKT1 polymorphisms are associated with susceptibility to pulmonary TB.
AKT1 是一种丝氨酸/苏氨酸激酶，在控制结核分枝杆菌的细胞内生长中起着关键作用。在这项研究中，我们研究了 AKT1 多态性是否影响结核病（TB）的易感性。通过聚合酶链反应-限制性片段长度多态性，我们对中国肺结核患者的 AKT1 两个单核苷酸多态性 IVS3+18C>T 和+726G>A 进行了基因分型。与年龄、性别和种族匹配的对照组相比，肺结核患者的 IVS3+18 C/C 基因型明显较低，C/T 基因型明显较高（P<0.05）。T-A 单倍型频率在患者中明显高于对照组（P<0.05）。总之，我们的结果表明 AKT1 多态性与肺结核易感性有关。
