Aslam Muhammad, Anwar Muhammad Asim, Khan Iqbal Saifullah
Department of Cardiology, Pakistan Institute of Medical Sciences, Islamabad.
J Coll Physicians Surg Pak. 2010 Jan;20(1):6-9.
To determine the sensitivity and specificity of thallium scintigraphy in detection of coronary artery disease in diabetic patients.
Cross-sectional validation study.
The study was carried out from July to December 2007 in the Cardiology Department of the Pakistan Institute of Medical Sciences, Islamabad.
A total of 60 diabetic patients suspected of having coronary artery disease were studied. Systematic probability sampling technique was used during their selection. All the patients underwent thallium scintigraphy followed by coronary angiography, which was used as gold standard test.
Out of 60 patients, 44 had positive thallium scintigraphy and 16 were negative. Likewise, 46 had positive angiography and 14 were negative. Out of 46 patients with positive angiography, thallium scintigraphy was positive in 41 subjects (sensitivity 89%) and false negative in only 5 of the 46 patients. Out of 14 patients with negative angiography, 11 patients had a negative thallium scintigraphy (specificity 79%) and the remaining 3 had a positive thallium scintigraphy. This gives thallium scintigraphy a positive predictive value of 93% and a negative predictive value of 69% when compared with angiography.
Thallium scintigraphy is a useful modality in the detection of coronary artery disease in diabetic patients.
确定铊闪烁扫描术检测糖尿病患者冠状动脉疾病的敏感性和特异性。
横断面验证研究。
2007年7月至12月在伊斯兰堡巴基斯坦医学科学研究所心脏病科进行该研究。
共研究了60例疑似患有冠状动脉疾病的糖尿病患者。在选择患者时采用系统概率抽样技术。所有患者均接受铊闪烁扫描术，随后进行冠状动脉造影，冠状动脉造影被用作金标准检测。
60例患者中，铊闪烁扫描术阳性44例，阴性16例。同样，冠状动脉造影阳性46例，阴性14例。在46例冠状动脉造影阳性的患者中，铊闪烁扫描术在41例患者中呈阳性（敏感性89%），在46例患者中仅5例为假阴性。在14例冠状动脉造影阴性的患者中，11例患者铊闪烁扫描术为阴性（特异性79%），其余3例铊闪烁扫描术为阳性。与冠状动脉造影相比，铊闪烁扫描术的阳性预测值为93%，阴性预测值为69%。
铊闪烁扫描术是检测糖尿病患者冠状动脉疾病的一种有用方法。
