Jones Peter H
Lipid Metabolism and Atherosclerosis Clinic, Baylor College of Medicine, Houston, TX, USA.
J Fam Pract. 2010 Feb;59(2):E1.
Clinical trials demonstrate that cardiovascular event rates diminish as low-density lipoprotein (LDL)-cholesterol and apolipoprotein B-containing particles are lowered with statin treatment. The relationship between LDL-cholesterol and cardiovascular events seems to be linear, with no lowest threshold. While LDL-cholesterol remains the primary target for coronary heart disease prevention, non-HDL-cholesterol is an important secondary target in patients with mixed dyslipidemia.
临床试验表明，使用他汀类药物治疗使低密度脂蛋白（LDL）胆固醇和含载脂蛋白B的颗粒降低时，心血管事件发生率会下降。LDL胆固醇与心血管事件之间的关系似乎呈线性，不存在最低阈值。虽然LDL胆固醇仍然是冠心病预防的主要目标，但对于混合性血脂异常患者，非HDL胆固醇是一个重要的次要目标。
